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Article: Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets

TitleSelection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets
Authors
Zhao, PChen, ZTLi, YZSun, DWGao, YHuang, YYLi, X
KeywordsDNA
DNA-encoded library
DNA-templated chemistry
drug discovery
selection
Issue Date2014
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie (International Edition), 2014, v. 53 n. 38, p. 10056-10059 How to Cite?
DOI: http://dx.doi.org/10.1002/anie.201404830
AbstractThe selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/221115
ISSN
1433-7851
2021 Impact Factor: 16.823
2020 SCImago Journal Rankings: 5.831
ISI Accession Number ID
WOS:000342761700008

 

DC FieldValueLanguage
dc.contributor.authorZhao, P-
dc.contributor.authorChen, ZT-
dc.contributor.authorLi, YZ-
dc.contributor.authorSun, DW-
dc.contributor.authorGao, Y-
dc.contributor.authorHuang, YY-
dc.contributor.authorLi, X-
dc.date.accessioned2015-10-27T08:30:19Z-
dc.date.available2015-10-27T08:30:19Z-
dc.date.issued2014-
dc.identifier.citationAngewandte Chemie (International Edition), 2014, v. 53 n. 38, p. 10056-10059-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/221115-
dc.description.abstractThe selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home-
dc.relation.ispartofAngewandte Chemie (International Edition)-
dc.rightspostprint: This is the accepted version of the following article: FULL CITE, which has been published in final form at [Link to final article]. Preprint This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article].-
dc.subjectDNA-
dc.subjectDNA-encoded library-
dc.subjectDNA-templated chemistry-
dc.subjectdrug discovery-
dc.subjectselection-
dc.titleSelection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets-
dc.typeArticle-
dc.identifier.emailLi, X: xiaoyuli@hku.hk-
dc.identifier.authorityLi, X=rp02080-
dc.identifier.doi10.1002/anie.201404830-
dc.identifier.pmid25044298-
dc.identifier.scopuseid_2-s2.0-84923301851-
dc.identifier.hkuros284524-
dc.identifier.volume53-
dc.identifier.issue38-
dc.identifier.spage10056-
dc.identifier.epage10059-
dc.identifier.isiWOS:000342761700008-
dc.publisher.placeGermany-
dc.identifier.issnl1433-7851-

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