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- Publisher Website: 10.1021/ja409936r
- Scopus: eid_2-s2.0-84889241150
- PMID: 24229415
- WOS: WOS:000328099400019
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Article: Multistep DNA-Templated Synthesis Using a Universal Template
Title | Multistep DNA-Templated Synthesis Using a Universal Template |
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Authors | |
Issue Date | 2013 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html |
Citation | Journal of the American Chemical Society, 2013, v. 135 n. 47, p. 17727-17730 How to Cite? |
Abstract | We report a DNA-templated synthesis method that allows construction of the entire DNA-encoded library with a single DNA template. Taking advantage of deoxyinosine's indiscriminate base-pairing property, we designed a 'universal template' that is capable of directing chemical reactions with multiple reactant DNAs with different sequences. In combination with other design features including photocleavable linkers and direct encoding by the reactant DNA, we demonstrated the capabilities of the universal template in library synthesis, target selection, and hit decoding. Our method can be generally and straightforwardly applied to prepare a variety of chemically diverse DNA-encoded libraries. © 2013 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/221119 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, Y | - |
dc.contributor.author | Zhao, P | - |
dc.contributor.author | Zhang, M | - |
dc.contributor.author | Zhao, X | - |
dc.contributor.author | Li, X | - |
dc.date.accessioned | 2015-10-27T09:08:02Z | - |
dc.date.available | 2015-10-27T09:08:02Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2013, v. 135 n. 47, p. 17727-17730 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/221119 | - |
dc.description.abstract | We report a DNA-templated synthesis method that allows construction of the entire DNA-encoded library with a single DNA template. Taking advantage of deoxyinosine's indiscriminate base-pairing property, we designed a 'universal template' that is capable of directing chemical reactions with multiple reactant DNAs with different sequences. In combination with other design features including photocleavable linkers and direct encoding by the reactant DNA, we demonstrated the capabilities of the universal template in library synthesis, target selection, and hit decoding. Our method can be generally and straightforwardly applied to prepare a variety of chemically diverse DNA-encoded libraries. © 2013 American Chemical Society. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | Multistep DNA-Templated Synthesis Using a Universal Template | - |
dc.type | Article | - |
dc.identifier.email | Li, X: xiaoyuli@hku.hk | - |
dc.identifier.authority | Li, X=rp02080 | - |
dc.identifier.doi | 10.1021/ja409936r | - |
dc.identifier.pmid | 24229415 | - |
dc.identifier.scopus | eid_2-s2.0-84889241150 | - |
dc.identifier.hkuros | 284527 | - |
dc.identifier.volume | 135 | - |
dc.identifier.issue | 47 | - |
dc.identifier.spage | 17727 | - |
dc.identifier.epage | 17730 | - |
dc.identifier.isi | WOS:000328099400019 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0002-7863 | - |