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Article: A study of the efficiency of pooling in haplotype estimation

TitleA study of the efficiency of pooling in haplotype estimation
Authors
Kuk, AYCXu, JYang, Y
KeywordsAlgorithms
Haplotypes
Issue Date2010
Citation
Bioinformatics (Oxford, England), 2010, v. 26, n. 20, p. 2556-2563 How to Cite?
DOI: http://dx.doi.org/10.1093/bioinformatics/btq492
AbstractIt has been claimed in the literature that pooling DNA samples is efficient in estimating haplotype frequencies. There is, however, no theoretical justification based on calculation of statistical efficiency. In fact, the limited evidence given so far is based on simulation studies with small numbers of loci. With rapid advance in technology, it is of interest to see if pooling is still efficient when the number of loci increases.
Persistent Identifierhttp://hdl.handle.net/10722/221687
ISSN
1367-4803
2021 Impact Factor: 6.931
2020 SCImago Journal Rankings: 3.599
ISI Accession Number ID
WOS:000282749700008

 

DC FieldValueLanguage
dc.contributor.authorKuk, AYC-
dc.contributor.authorXu, J-
dc.contributor.authorYang, Y-
dc.date.accessioned2015-12-04T15:29:07Z-
dc.date.available2015-12-04T15:29:07Z-
dc.date.issued2010-
dc.identifier.citationBioinformatics (Oxford, England), 2010, v. 26, n. 20, p. 2556-2563-
dc.identifier.issn1367-4803-
dc.identifier.urihttp://hdl.handle.net/10722/221687-
dc.description.abstractIt has been claimed in the literature that pooling DNA samples is efficient in estimating haplotype frequencies. There is, however, no theoretical justification based on calculation of statistical efficiency. In fact, the limited evidence given so far is based on simulation studies with small numbers of loci. With rapid advance in technology, it is of interest to see if pooling is still efficient when the number of loci increases.-
dc.languageeng-
dc.relation.ispartofBioinformatics (Oxford, England)-
dc.subjectAlgorithms-
dc.subjectHaplotypes-
dc.titleA study of the efficiency of pooling in haplotype estimation-
dc.typeArticle-
dc.identifier.emailXu, J: xujf@hku.hk-
dc.identifier.authorityXu, J=rp02086-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/bioinformatics/btq492-
dc.identifier.pmid20801910-
dc.identifier.scopuseid_2-s2.0-77957768673-
dc.identifier.volume26-
dc.identifier.spage2556-
dc.identifier.epage2563-
dc.identifier.isiWOS:000282749700008-
dc.identifier.issnl1367-4803-

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