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- Publisher Website: 10.1161/CIRCINTERVENTIONS.115.002626
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Article: Everolimus eluting stents versus coronary artery bypass graft surgery for patients with diabetes mellitus and multivessel disease
Title | Everolimus eluting stents versus coronary artery bypass graft surgery for patients with diabetes mellitus and multivessel disease |
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Authors | |
Keywords | Coronary Artery Bypass Graft Diabetes Mellitus Multivessel Disease Percutaneous Coronary Intervention |
Issue Date | 2015 |
Citation | Circulation: Cardiovascular Interventions, 2015, v. 8, article no. e002626 How to Cite? |
Abstract | Background-In patients with diabetes mellitus and multivessel disease, coronary artery bypass graft surgery and percutaneous coronary intervention are treatment options. However, there is paucity of data comparing coronary artery bypass graft surgery against newer generation stents. Methods and Results-Patients included in the New York State registries who had diabetes mellitus and underwent isolated coronary artery bypass graft surgery or percutaneous coronary intervention with everolimus eluting stent (EES) for multivessel disease were included. Propensity score matching was used to assemble a cohort with similar baseline characteristics. The primary outcome was all-cause mortality. Secondary outcomes were myocardial infarction (MI), stroke, and repeat revascularization. Short-term (within 30 days) and long-term outcomes were evaluated. Among 16 089 patients with diabetes mellitus and multivessel disease, 8096 patients with similar propensity scores were included. At short-term, EES was associated with a lower risk of death (hazard ratio [HR] =0.58; 95% confidence interval [CI], 0.34-0.98; P=0.04) and stroke (HR=0.14; 95% CI, 0.06-0.30; P0.0001) but higher risk of MI (HR=2.44; 95% CI, 1.13-5.31; P=0.02). At long-term, EES was associated with a similar risk of death (425 [10.50%] versus 414 [10.23%] events; HR=1.12; 95% CI, 0.96-1.30; P=0.16), a lower risk of stroke (118 [2.92%] versus 157 [3.88%] events; HR=0.76; 95% CI, 0.58-0.99; P=0.04) but a higher risk of MI (260 [6.42%] versus 166 [4.10%] events; HR=1.64; 95% CI, 1.32-2.04; P0.0001) and repeat revascularization (889 [21.96%] versus 421 [10.40%] events; HR=2.42; 95% CI, 2.12-2.76; P0.0001). The higher risk of MI was not seen in the subgroup of EES patients who underwent complete revascularization (HR=1.37; 95% CI, 0.76-2.47; P=0.30). Conclusions-In patients with diabetes mellitus and multivessel disease, EES was associated with lower upfront risk of death and stroke when compared with coronary artery bypass graft surgery. However, at long-term, EES was associated with similar risk of death, a higher risk of MI (in those with incomplete revascularization), and repeat revascularization but a lower risk of stroke. © 2015 American Heart Association, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/221696 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 2.242 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bangalore, S | - |
dc.contributor.author | Guo, Y | - |
dc.contributor.author | Blecker, S | - |
dc.contributor.author | Samadashvili, Z | - |
dc.contributor.author | Xu, J | - |
dc.contributor.author | Hannan, EL | - |
dc.date.accessioned | 2015-12-04T15:29:10Z | - |
dc.date.available | 2015-12-04T15:29:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Circulation: Cardiovascular Interventions, 2015, v. 8, article no. e002626 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.uri | http://hdl.handle.net/10722/221696 | - |
dc.description.abstract | Background-In patients with diabetes mellitus and multivessel disease, coronary artery bypass graft surgery and percutaneous coronary intervention are treatment options. However, there is paucity of data comparing coronary artery bypass graft surgery against newer generation stents. Methods and Results-Patients included in the New York State registries who had diabetes mellitus and underwent isolated coronary artery bypass graft surgery or percutaneous coronary intervention with everolimus eluting stent (EES) for multivessel disease were included. Propensity score matching was used to assemble a cohort with similar baseline characteristics. The primary outcome was all-cause mortality. Secondary outcomes were myocardial infarction (MI), stroke, and repeat revascularization. Short-term (within 30 days) and long-term outcomes were evaluated. Among 16 089 patients with diabetes mellitus and multivessel disease, 8096 patients with similar propensity scores were included. At short-term, EES was associated with a lower risk of death (hazard ratio [HR] =0.58; 95% confidence interval [CI], 0.34-0.98; P=0.04) and stroke (HR=0.14; 95% CI, 0.06-0.30; P0.0001) but higher risk of MI (HR=2.44; 95% CI, 1.13-5.31; P=0.02). At long-term, EES was associated with a similar risk of death (425 [10.50%] versus 414 [10.23%] events; HR=1.12; 95% CI, 0.96-1.30; P=0.16), a lower risk of stroke (118 [2.92%] versus 157 [3.88%] events; HR=0.76; 95% CI, 0.58-0.99; P=0.04) but a higher risk of MI (260 [6.42%] versus 166 [4.10%] events; HR=1.64; 95% CI, 1.32-2.04; P0.0001) and repeat revascularization (889 [21.96%] versus 421 [10.40%] events; HR=2.42; 95% CI, 2.12-2.76; P0.0001). The higher risk of MI was not seen in the subgroup of EES patients who underwent complete revascularization (HR=1.37; 95% CI, 0.76-2.47; P=0.30). Conclusions-In patients with diabetes mellitus and multivessel disease, EES was associated with lower upfront risk of death and stroke when compared with coronary artery bypass graft surgery. However, at long-term, EES was associated with similar risk of death, a higher risk of MI (in those with incomplete revascularization), and repeat revascularization but a lower risk of stroke. © 2015 American Heart Association, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Circulation: Cardiovascular Interventions | - |
dc.subject | Coronary Artery Bypass Graft | - |
dc.subject | Diabetes Mellitus | - |
dc.subject | Multivessel Disease | - |
dc.subject | Percutaneous Coronary Intervention | - |
dc.title | Everolimus eluting stents versus coronary artery bypass graft surgery for patients with diabetes mellitus and multivessel disease | - |
dc.type | Article | - |
dc.identifier.email | Xu, J: xujf@hku.hk | - |
dc.identifier.authority | Xu, J=rp02086 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.115.002626 | - |
dc.identifier.scopus | eid_2-s2.0-84942796647 | - |
dc.identifier.hkuros | 260479 | - |
dc.identifier.volume | 8 | - |
dc.identifier.spage | article no. e002626 | - |
dc.identifier.epage | article no. e002626 | - |
dc.identifier.isi | WOS:000390404100010 | - |
dc.identifier.issnl | 1941-7640 | - |