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- Publisher Website: 10.1504/IJDMB.2012.045543
- Scopus: eid_2-s2.0-84857757576
- PMID: 22479821
- WOS: WOS:000300730800007
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Article: IMOWSE, a scoring scheme bridging in silico and in vitro digestion in PMF
Title | IMOWSE, a scoring scheme bridging in silico and in vitro digestion in PMF |
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Authors | |
Keywords | MOWSE PMF Molecular weight search Peptide mass fingerprinting |
Issue Date | 2012 |
Citation | International Journal of Data Mining and Bioinformatics, 2012, v. 6, n. 1, p. 104-113 How to Cite? |
Abstract | We demonstrated an unexplored issue in Peptide Mass Fingerprinting, 'cleavage site clusters', and formulated iMOWSE to distinguish true positives from false positives. We showed how the cleavage site clusters skew peptide database composition. Concerning the information content of an in silico digestion of a protein, both the number of matches of long peptides and the number of such peptides an entry can generate are taken into account. The resultant iMOWSE allows tolerance of deviation of query mass values from theoretical mass values and fewer matches are needed to identify true positives. Copyright © 2012 Inderscience Enterprises Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/222177 |
ISSN | 2023 Impact Factor: 0.2 2023 SCImago Journal Rankings: 0.173 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Leung, Ross K K | - |
dc.contributor.author | Tsui, Stephen K W | - |
dc.date.accessioned | 2015-12-21T06:49:11Z | - |
dc.date.available | 2015-12-21T06:49:11Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | International Journal of Data Mining and Bioinformatics, 2012, v. 6, n. 1, p. 104-113 | - |
dc.identifier.issn | 1748-5673 | - |
dc.identifier.uri | http://hdl.handle.net/10722/222177 | - |
dc.description.abstract | We demonstrated an unexplored issue in Peptide Mass Fingerprinting, 'cleavage site clusters', and formulated iMOWSE to distinguish true positives from false positives. We showed how the cleavage site clusters skew peptide database composition. Concerning the information content of an in silico digestion of a protein, both the number of matches of long peptides and the number of such peptides an entry can generate are taken into account. The resultant iMOWSE allows tolerance of deviation of query mass values from theoretical mass values and fewer matches are needed to identify true positives. Copyright © 2012 Inderscience Enterprises Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Data Mining and Bioinformatics | - |
dc.subject | MOWSE | - |
dc.subject | PMF | - |
dc.subject | Molecular weight search | - |
dc.subject | Peptide mass fingerprinting | - |
dc.title | IMOWSE, a scoring scheme bridging in silico and in vitro digestion in PMF | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1504/IJDMB.2012.045543 | - |
dc.identifier.pmid | 22479821 | - |
dc.identifier.scopus | eid_2-s2.0-84857757576 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 104 | - |
dc.identifier.epage | 113 | - |
dc.identifier.eissn | 1748-5681 | - |
dc.identifier.isi | WOS:000300730800007 | - |
dc.identifier.issnl | 1748-5673 | - |