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- Publisher Website: 10.1111/j.1476-5381.1989.tb11899.x
- Scopus: eid_2-s2.0-0024536579
- PMID: 2743083
- WOS: WOS:A1989T947700021
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Article: Arterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation
Title | Arterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation |
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Authors | |
Issue Date | 1989 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 |
Citation | British Journal of Pharmacology, 1989, v. 96 n. 4, p. 888-894 How to Cite? |
Abstract | 1 The effect of acute or chronic morphine treatment on the changes in arterial noradrenaline and adrenaline levels in response to sympathetic nerve stimulation was studied in rats.
2 Rats which had been chronically treated with morphine in their drinking fluid for 21 days were shown to be morphine-tolerant, as revealed by the tail-immersion test for analgesia.
3 It was found that animals given either acute or chronic morphine treatment had similar basal concentrations of arterial catecholamines to their controls.
4 Sympathetic nerve stimulation produced significant increases in arterial noradrenaline and adrenaline levels in both the control and morphine-treated animals. However, the degree of arterial noradrenaline elevation was significantly less in morphine-tolerant animals.
5 This phenomenon was not observed in acutely morphine-treated rats or at 2 weeks following opiate withdrawal in animals which had been treated previously with morphine for 3 weeks.
6 The findings suggest that chronic morphine treatment in rats not only leads to opiate tolerance but also reduces catecholamine release in response to sympathetic nerve stimulation. |
Persistent Identifier | http://hdl.handle.net/10722/222859 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 2.119 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Leung, CMK | - |
dc.contributor.author | Dai, S | - |
dc.contributor.author | Ogle, CW | - |
dc.date.accessioned | 2016-02-05T02:48:10Z | - |
dc.date.available | 2016-02-05T02:48:10Z | - |
dc.date.issued | 1989 | - |
dc.identifier.citation | British Journal of Pharmacology, 1989, v. 96 n. 4, p. 888-894 | - |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.uri | http://hdl.handle.net/10722/222859 | - |
dc.description.abstract | 1 The effect of acute or chronic morphine treatment on the changes in arterial noradrenaline and adrenaline levels in response to sympathetic nerve stimulation was studied in rats. 2 Rats which had been chronically treated with morphine in their drinking fluid for 21 days were shown to be morphine-tolerant, as revealed by the tail-immersion test for analgesia. 3 It was found that animals given either acute or chronic morphine treatment had similar basal concentrations of arterial catecholamines to their controls. 4 Sympathetic nerve stimulation produced significant increases in arterial noradrenaline and adrenaline levels in both the control and morphine-treated animals. However, the degree of arterial noradrenaline elevation was significantly less in morphine-tolerant animals. 5 This phenomenon was not observed in acutely morphine-treated rats or at 2 weeks following opiate withdrawal in animals which had been treated previously with morphine for 3 weeks. 6 The findings suggest that chronic morphine treatment in rats not only leads to opiate tolerance but also reduces catecholamine release in response to sympathetic nerve stimulation. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 | - |
dc.relation.ispartof | British Journal of Pharmacology | - |
dc.title | Arterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/j.1476-5381.1989.tb11899.x | - |
dc.identifier.pmid | 2743083 | - |
dc.identifier.pmcid | PMC1854453 | - |
dc.identifier.scopus | eid_2-s2.0-0024536579 | - |
dc.identifier.hkuros | 139667 | - |
dc.identifier.volume | 96 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 888 | - |
dc.identifier.epage | 894 | - |
dc.identifier.isi | WOS:A1989T947700021 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0007-1188 | - |