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Article: Alternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin’s Lymphoma
Title | Alternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin’s Lymphoma |
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Authors | |
Issue Date | 2002 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | Cancer Research, 2002, v. 62 n. 14, p. 4089-4094 How to Cite? |
Abstract | Chromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. In a fraction of these translocations, the chromosomal breakpoint is located within the 5' noncoding region of the BCL-6 proto-oncogene where the BCL-6 major breakpoint region (MBR) maps. As a result of the translocation, BCL-6 expression is deregulated by promoter substitution. However, between 30 and 50% of lymphomas with cytogenetically detectable translocations affecting band 3q27 retain a germ-line configuration at the BCL-6 locus. To identify possible additional breakpoint clusters within 3q27, we cloned a t(3;14)(q27;q32) lymphoma without MBR rearrangement and found a novel breakpoint site located between 245 and 285 kb 5' to BCL-6. Breakpoints within this newly described region, which we called the alternative breakpoint region (ABR), were found to be recurrent in lymphomas carrying t(3q27) chromosomal translocations but devoid of BCL-6 MBR rearrangements. Comparative analysis of multiple lymphomas carrying rearrangements within the ABR showed that the breakpoints cluster within a 20-kb distance. Translocations involving the ABR may juxtapose BCL-6 to distantly acting, heterologous transcriptional regulatory elements which cause deregulation of the proto-oncogene. The identification of BCL-6 ABR provides new tools for the diagnosis of lymphomas carrying aberrations at 3q27 and deregulated BCL-6 genes. |
Persistent Identifier | http://hdl.handle.net/10722/222878 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
DC Field | Value | Language |
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dc.contributor.author | Butler, MP | - |
dc.contributor.author | Iida, S | - |
dc.contributor.author | Capello, D | - |
dc.contributor.author | Rao, PH | - |
dc.contributor.author | Rossi, D | - |
dc.contributor.author | Nallasivam, P | - |
dc.contributor.author | Louie, DC | - |
dc.contributor.author | Chaganti, S | - |
dc.contributor.author | Au, T | - |
dc.contributor.author | Gascoyne, RD | - |
dc.contributor.author | Gaidano, G | - |
dc.contributor.author | Chaganti, RSK | - |
dc.contributor.author | Dalla-Favera, R | - |
dc.date.accessioned | 2016-02-05T06:49:05Z | - |
dc.date.available | 2016-02-05T06:49:05Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Cancer Research, 2002, v. 62 n. 14, p. 4089-4094 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/222878 | - |
dc.description.abstract | Chromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. In a fraction of these translocations, the chromosomal breakpoint is located within the 5' noncoding region of the BCL-6 proto-oncogene where the BCL-6 major breakpoint region (MBR) maps. As a result of the translocation, BCL-6 expression is deregulated by promoter substitution. However, between 30 and 50% of lymphomas with cytogenetically detectable translocations affecting band 3q27 retain a germ-line configuration at the BCL-6 locus. To identify possible additional breakpoint clusters within 3q27, we cloned a t(3;14)(q27;q32) lymphoma without MBR rearrangement and found a novel breakpoint site located between 245 and 285 kb 5' to BCL-6. Breakpoints within this newly described region, which we called the alternative breakpoint region (ABR), were found to be recurrent in lymphomas carrying t(3q27) chromosomal translocations but devoid of BCL-6 MBR rearrangements. Comparative analysis of multiple lymphomas carrying rearrangements within the ABR showed that the breakpoints cluster within a 20-kb distance. Translocations involving the ABR may juxtapose BCL-6 to distantly acting, heterologous transcriptional regulatory elements which cause deregulation of the proto-oncogene. The identification of BCL-6 ABR provides new tools for the diagnosis of lymphomas carrying aberrations at 3q27 and deregulated BCL-6 genes. | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
dc.relation.ispartof | Cancer Research | - |
dc.subject.mesh | Chromosomes, Human, Pair 3 | - |
dc.subject.mesh | DNA-Binding Proteins - genetics | - |
dc.subject.mesh | Lymphoma, B-Cell - genetics | - |
dc.subject.mesh | Proto-Oncogene Proteins - genetics | - |
dc.subject.mesh | Transcription Factors - genetics | - |
dc.title | Alternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin’s Lymphoma | - |
dc.type | Article | - |
dc.identifier.email | Au, T: auwing@hkucc.hku.hk | - |
dc.identifier.pmid | 12124346 | - |
dc.identifier.hkuros | 77922 | - |
dc.identifier.volume | 62 | - |
dc.identifier.issue | 14 | - |
dc.identifier.spage | 4089 | - |
dc.identifier.epage | 4094 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0008-5472 | - |