File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.4103/1673-5374.172315
- Scopus: eid_2-s2.0-84953334407
- WOS: WOS:000368926200025
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells
Title | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
---|---|
Authors | |
Keywords | Adult Lycium barbarum (wolfberry) Lycium barbarum polysaccharides Nerve regeneration Neural regeneration Neurogenesis Retinal disease Traditional Chinese medicine |
Issue Date | 2015 |
Publisher | Medknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/ |
Citation | Neural Regeneration Research, 2015, v. 10 n. 12, p. 1976-1981 How to Cite? |
Abstract | Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low - and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype. |
Persistent Identifier | http://hdl.handle.net/10722/223988 |
ISSN | 2023 Impact Factor: 5.9 2023 SCImago Journal Rankings: 0.967 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, H | - |
dc.contributor.author | Lau, BWM | - |
dc.contributor.author | Wang, NL | - |
dc.contributor.author | Wang, SY | - |
dc.contributor.author | Lu, QJ | - |
dc.contributor.author | Chang, RCC | - |
dc.contributor.author | So, KF | - |
dc.date.accessioned | 2016-03-18T02:33:22Z | - |
dc.date.available | 2016-03-18T02:33:22Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Neural Regeneration Research, 2015, v. 10 n. 12, p. 1976-1981 | - |
dc.identifier.issn | 1673-5374 | - |
dc.identifier.uri | http://hdl.handle.net/10722/223988 | - |
dc.description.abstract | Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low - and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype. | - |
dc.language | eng | - |
dc.publisher | Medknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/ | - |
dc.relation.ispartof | Neural Regeneration Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Adult | - |
dc.subject | Lycium barbarum (wolfberry) | - |
dc.subject | Lycium barbarum polysaccharides | - |
dc.subject | Nerve regeneration | - |
dc.subject | Neural regeneration | - |
dc.subject | Neurogenesis | - |
dc.subject | Retinal disease | - |
dc.subject | Traditional Chinese medicine | - |
dc.title | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells | - |
dc.type | Article | - |
dc.identifier.email | Chang, RCC: rccchang@hku.hk | - |
dc.identifier.email | So, KF: hrmaskf@hku.hk | - |
dc.identifier.authority | Chang, RCC=rp00470 | - |
dc.identifier.authority | So, KF=rp00329 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.4103/1673-5374.172315 | - |
dc.identifier.scopus | eid_2-s2.0-84953334407 | - |
dc.identifier.hkuros | 257206 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1976 | - |
dc.identifier.epage | 1981 | - |
dc.identifier.isi | WOS:000368926200025 | - |
dc.publisher.place | China | - |
dc.identifier.issnl | 1673-5374 | - |