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Conference Paper: Central administration of secretin suppresses food intake in mice
Title | Central administration of secretin suppresses food intake in mice |
---|---|
Authors | |
Issue Date | 2010 |
Publisher | Humana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/neuroscience/journal/12031 |
Citation | The 9th International Symposium on VIP, PACAP, and Related Peptides, Kagoshima, Japan, 5-8 October 2009. In Journal of Molecular Neuroscience, 2010, v. 42 n. 3, p. 285 How to Cite? |
Abstract | Secretin is released into the circulation postprandially from the
duodenal S cells. The major functions of secretin originated
from the gastrointestinal system are to delay gastric emptying,
stimulate fluid secretion from pancreas and liver, and hence,
optimize the digestion process. In our laboratory, secretin and
its receptor have recently been identified in mice hypothalamus
where it has long been considered as an important center
in the regulation of energy homeostasis. By altering the rate at
which nutrients are delivered to compartments of the
alimentary canal and being highly expressed in hypothalamic
nuclei, secretin could therefore be involved in appetite control.
In this study, the functional role of secretin on feeding
regulation was investigated. Intracerebroventricular (ICV)
administration of secretin (0.15 nmol) into the lateral ventricle
was found to suppress food intake in both fasted mice or ad
libitum fed wild-type mice but not in fasted mice or ad libitum
fed secretin receptor knockout mice (SCTR−/−). In addition,
central administration of secretin could induce Fos expression
in hypothalamic nuclei, including the paraventricular nucleus
(PVN) and the arcuate nucleus (Arc). Consistent with these
findings, ICV-secretin could also change expressions of
appetite control proteins in various hypothalamic nuclei. It
could activate proopiomelanocortin (POMC), reduce agoutirelated
protein (AgRP) mRNA expression in the Arc, and
increase thyrotropin-releasing hormone (TRH) transcripts in
the PVN, while these effects of ICV-secretin were not found in
SCTR−/−. Altogether, our data suggest that secretin, via its
receptor, could inhibit food intake and that this action could be
mediated by changing the expressions of POMC and AgRP in
the Arc and TRH in the PVN. |
Description | Session 5: Endocrine System and Metabolism: no. O13 This journal issue entitled: Special Issue: VIP, PACAP and Related Peptides |
Persistent Identifier | http://hdl.handle.net/10722/224421 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.747 |
DC Field | Value | Language |
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dc.contributor.author | Cheng, YY | - |
dc.contributor.author | Chu, JYS | - |
dc.contributor.author | Chow, BKC | - |
dc.date.accessioned | 2016-04-05T03:05:26Z | - |
dc.date.available | 2016-04-05T03:05:26Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | The 9th International Symposium on VIP, PACAP, and Related Peptides, Kagoshima, Japan, 5-8 October 2009. In Journal of Molecular Neuroscience, 2010, v. 42 n. 3, p. 285 | - |
dc.identifier.issn | 0895-8696 | - |
dc.identifier.uri | http://hdl.handle.net/10722/224421 | - |
dc.description | Session 5: Endocrine System and Metabolism: no. O13 | - |
dc.description | This journal issue entitled: Special Issue: VIP, PACAP and Related Peptides | - |
dc.description.abstract | Secretin is released into the circulation postprandially from the duodenal S cells. The major functions of secretin originated from the gastrointestinal system are to delay gastric emptying, stimulate fluid secretion from pancreas and liver, and hence, optimize the digestion process. In our laboratory, secretin and its receptor have recently been identified in mice hypothalamus where it has long been considered as an important center in the regulation of energy homeostasis. By altering the rate at which nutrients are delivered to compartments of the alimentary canal and being highly expressed in hypothalamic nuclei, secretin could therefore be involved in appetite control. In this study, the functional role of secretin on feeding regulation was investigated. Intracerebroventricular (ICV) administration of secretin (0.15 nmol) into the lateral ventricle was found to suppress food intake in both fasted mice or ad libitum fed wild-type mice but not in fasted mice or ad libitum fed secretin receptor knockout mice (SCTR−/−). In addition, central administration of secretin could induce Fos expression in hypothalamic nuclei, including the paraventricular nucleus (PVN) and the arcuate nucleus (Arc). Consistent with these findings, ICV-secretin could also change expressions of appetite control proteins in various hypothalamic nuclei. It could activate proopiomelanocortin (POMC), reduce agoutirelated protein (AgRP) mRNA expression in the Arc, and increase thyrotropin-releasing hormone (TRH) transcripts in the PVN, while these effects of ICV-secretin were not found in SCTR−/−. Altogether, our data suggest that secretin, via its receptor, could inhibit food intake and that this action could be mediated by changing the expressions of POMC and AgRP in the Arc and TRH in the PVN. | - |
dc.language | eng | - |
dc.publisher | Humana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/neuroscience/journal/12031 | - |
dc.relation.ispartof | Journal of Molecular Neuroscience | - |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s12031-009-9324-2 | - |
dc.title | Central administration of secretin suppresses food intake in mice | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chu, JYS: hitan@graduate.hku.hk | - |
dc.identifier.email | Chow, BKC: bkcc@hkusua.hku.hk | - |
dc.identifier.authority | Chu, JYS=rp00684 | - |
dc.identifier.authority | Chow, BKC=rp00681 | - |
dc.identifier.doi | 10.1007/s12031-009-9324-2 | - |
dc.identifier.hkuros | 181135 | - |
dc.identifier.volume | 42 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 285 | - |
dc.identifier.epage | 285 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0895-8696 | - |