File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function

TitleThe Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function
Authors
KeywordsSmoking
Obstructive sleep apnea
Biomarkers
Endothelial function
Issue Date2016
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/RES
Citation
Respiration, 2016, v. 91 n. 2, p. 124-131 How to Cite?
AbstractBackground: Endothelial dysfunction has been recognized to occur in the context of obstructive sleep apnea (OSA) or tobacco smoking. However, the deleterious effect on vascular function with concurrence of both conditions is largely unknown. Objective: To investigate whether the concurrence of OSA and smoking poses an additive detriment to endothelial dysfunction. Methods: Chinese men without a history of chronic medical illness were invited to complete a questionnaire including smoking pack-year exposure, polysomnography and peripheral arterial tonometry (PAT) for endothelial function. Serum 8-isoprostane, advanced oxidation protein products (AOPP) and monocyte chemo-attractant protein-1 (MCP-1) were measured. Results: 114 men were successfully enrolled. PAT ratio, adjusted for age and body mass index, correlated inversely with overall severity of OSA: apnea-hypopnea index (AHI), r = -0.160 (p = 0.092); oxygen desaturation index, r = -0.214 (p = 0.024); duration of oxygen saturation <90%, r = -0.219 (p = 0.020); and minimum oxygen saturation, r = 0.250 (p = 0.008). The PAT ratio decreased with increasing pack-year group (p = 0.018). It was lower with concurrent smoking history and moderate-severe OSA (AHI ≥15/h) compared to having one or neither factor (p = 0.011). Serum levels of 8-isoprostane and AOPP were positively related to severity of OSA, while MCP-1 correlated with smoking quantity. Multiple linear regression analyses showed that severity of intermittent hypoxia, MCP-1 and pack-year exposure were independent predictors of PAT ratio. Conclusion: While OSA, in particular intermittent hypoxemia, and tobacco smoking were independent risk factors, the concurrence of moderate-severe OSA and smoking was associated with the most severe impairment in endothelial function.
Persistent Identifierhttp://hdl.handle.net/10722/224938
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.050
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLui, MMS-
dc.contributor.authorMak, JCW-
dc.contributor.authorLai, AYK-
dc.contributor.authorHui, CKM-
dc.contributor.authorLam, JCM-
dc.contributor.authorLam, DCL-
dc.contributor.authorIp, MSM-
dc.date.accessioned2016-04-18T03:34:18Z-
dc.date.available2016-04-18T03:34:18Z-
dc.date.issued2016-
dc.identifier.citationRespiration, 2016, v. 91 n. 2, p. 124-131-
dc.identifier.issn0025-7931-
dc.identifier.urihttp://hdl.handle.net/10722/224938-
dc.description.abstractBackground: Endothelial dysfunction has been recognized to occur in the context of obstructive sleep apnea (OSA) or tobacco smoking. However, the deleterious effect on vascular function with concurrence of both conditions is largely unknown. Objective: To investigate whether the concurrence of OSA and smoking poses an additive detriment to endothelial dysfunction. Methods: Chinese men without a history of chronic medical illness were invited to complete a questionnaire including smoking pack-year exposure, polysomnography and peripheral arterial tonometry (PAT) for endothelial function. Serum 8-isoprostane, advanced oxidation protein products (AOPP) and monocyte chemo-attractant protein-1 (MCP-1) were measured. Results: 114 men were successfully enrolled. PAT ratio, adjusted for age and body mass index, correlated inversely with overall severity of OSA: apnea-hypopnea index (AHI), r = -0.160 (p = 0.092); oxygen desaturation index, r = -0.214 (p = 0.024); duration of oxygen saturation <90%, r = -0.219 (p = 0.020); and minimum oxygen saturation, r = 0.250 (p = 0.008). The PAT ratio decreased with increasing pack-year group (p = 0.018). It was lower with concurrent smoking history and moderate-severe OSA (AHI ≥15/h) compared to having one or neither factor (p = 0.011). Serum levels of 8-isoprostane and AOPP were positively related to severity of OSA, while MCP-1 correlated with smoking quantity. Multiple linear regression analyses showed that severity of intermittent hypoxia, MCP-1 and pack-year exposure were independent predictors of PAT ratio. Conclusion: While OSA, in particular intermittent hypoxemia, and tobacco smoking were independent risk factors, the concurrence of moderate-severe OSA and smoking was associated with the most severe impairment in endothelial function.-
dc.languageeng-
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/RES-
dc.relation.ispartofRespiration-
dc.subjectSmoking-
dc.subjectObstructive sleep apnea-
dc.subjectBiomarkers-
dc.subjectEndothelial function-
dc.titleThe Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function-
dc.typeArticle-
dc.identifier.emailMak, JCW: judithmak@hku.hk-
dc.identifier.emailLai, AYK: agneslai@hku.hk-
dc.identifier.emailHui, CKM: chris.hui@hku.hk-
dc.identifier.emailLam, DCL: dcllam@hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.authorityMak, JCW=rp00352-
dc.identifier.authorityLai, AYK=rp02579-
dc.identifier.authorityHui, CKM=rp01839-
dc.identifier.authorityLam, DCL=rp01345-
dc.identifier.authorityIp, MSM=rp00347-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1159/000443527-
dc.identifier.pmid26784019-
dc.identifier.scopuseid_2-s2.0-84959138974-
dc.identifier.hkuros257407-
dc.identifier.hkuros273131-
dc.identifier.volume91-
dc.identifier.issue2-
dc.identifier.spage124-
dc.identifier.epage131-
dc.identifier.isiWOS:000370156600006-
dc.publisher.placeSwitzerland-
dc.identifier.issnl0025-7931-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats