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- Publisher Website: 10.1515/revneuro-2013-0014
- Scopus: eid_2-s2.0-84888173055
- PMID: 23828492
- WOS: WOS:000322972500005
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Article: Serine-arginine protein kinases: New players in neurodegenerative diseases?
Title | Serine-arginine protein kinases: New players in neurodegenerative diseases? |
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Authors | |
Keywords | Neurodegenerative disease Neuron Cell cycle Alternative splicing Tauopathy SRPK |
Issue Date | 2013 |
Citation | Reviews in the Neurosciences, 2013, v. 24, n. 4, p. 401-413 How to Cite? |
Abstract | Serine-arginine protein kinases (SRPKs) are a group of serine kinases that recognize and phosphorylate protein substrates with serine-arginine dipeptide repeats. They are mainly involved in regulating pre-mRNA splicing via phosphorylating splicing factors, such as ASF/SF2 and SC35. Nevertheless, the functions of SRPKs in the nervous system are sketchy, although the kinases have significant expression in neurons. Our recent studies demonstrate that one of the SRPK members, SRPK2, participates in the neuronal survival, cell cycle progression, and memory determination in Alzheimer's disease. SRPKs are thus a group of unrecognized proteins that may facilitate the pathological progression of disorders caused by neurodegeneration. In this review, we will update our knowledge on SRPKs' functions in various cellular activities and discuss their potential role in neurodegenerative disorders. |
Persistent Identifier | http://hdl.handle.net/10722/225056 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.108 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, Chi Bun | - |
dc.contributor.author | Ye, Keqiang | - |
dc.date.accessioned | 2016-04-18T11:16:38Z | - |
dc.date.available | 2016-04-18T11:16:38Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Reviews in the Neurosciences, 2013, v. 24, n. 4, p. 401-413 | - |
dc.identifier.issn | 0334-1763 | - |
dc.identifier.uri | http://hdl.handle.net/10722/225056 | - |
dc.description.abstract | Serine-arginine protein kinases (SRPKs) are a group of serine kinases that recognize and phosphorylate protein substrates with serine-arginine dipeptide repeats. They are mainly involved in regulating pre-mRNA splicing via phosphorylating splicing factors, such as ASF/SF2 and SC35. Nevertheless, the functions of SRPKs in the nervous system are sketchy, although the kinases have significant expression in neurons. Our recent studies demonstrate that one of the SRPK members, SRPK2, participates in the neuronal survival, cell cycle progression, and memory determination in Alzheimer's disease. SRPKs are thus a group of unrecognized proteins that may facilitate the pathological progression of disorders caused by neurodegeneration. In this review, we will update our knowledge on SRPKs' functions in various cellular activities and discuss their potential role in neurodegenerative disorders. | - |
dc.language | eng | - |
dc.relation.ispartof | Reviews in the Neurosciences | - |
dc.subject | Neurodegenerative disease | - |
dc.subject | Neuron | - |
dc.subject | Cell cycle | - |
dc.subject | Alternative splicing | - |
dc.subject | Tauopathy | - |
dc.subject | SRPK | - |
dc.title | Serine-arginine protein kinases: New players in neurodegenerative diseases? | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1515/revneuro-2013-0014 | - |
dc.identifier.pmid | 23828492 | - |
dc.identifier.scopus | eid_2-s2.0-84888173055 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 401 | - |
dc.identifier.epage | 413 | - |
dc.identifier.isi | WOS:000322972500005 | - |
dc.identifier.issnl | 0334-1763 | - |