File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.4161/23723556.2014.983388
- Scopus: eid_2-s2.0-85051533421
- WOS: WOS:000218570900039
Supplementary
- Citations:
- Appears in Collections:
Article: p85α neomorphic mutants: splitting away from the canonical path
Title | p85α neomorphic mutants: splitting away from the canonical path |
---|---|
Authors | |
Keywords | MAPK mutation neomorph p85a PI3K PIK3R1 |
Issue Date | 2015 |
Publisher | Taylor & Francis Inc.. The Journal's web site is located at http://www.tandfonline.com/kmco |
Citation | Molecular & Cellular Oncology, 2015, v. 2 n. 4, p. Article no. e983388 How to Cite? |
Abstract | PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy. |
Persistent Identifier | http://hdl.handle.net/10722/225117 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheung, WTL | - |
dc.contributor.author | Mills, GB | - |
dc.date.accessioned | 2016-04-22T01:22:07Z | - |
dc.date.available | 2016-04-22T01:22:07Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Molecular & Cellular Oncology, 2015, v. 2 n. 4, p. Article no. e983388 | - |
dc.identifier.uri | http://hdl.handle.net/10722/225117 | - |
dc.description.abstract | PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy. | - |
dc.language | eng | - |
dc.publisher | Taylor & Francis Inc.. The Journal's web site is located at http://www.tandfonline.com/kmco | - |
dc.relation.ispartof | Molecular & Cellular Oncology | - |
dc.subject | MAPK | - |
dc.subject | mutation | - |
dc.subject | neomorph | - |
dc.subject | p85a | - |
dc.subject | PI3K | - |
dc.subject | PIK3R1 | - |
dc.title | p85α neomorphic mutants: splitting away from the canonical path | - |
dc.type | Article | - |
dc.identifier.email | Cheung, WTL: lydiacwt@hku.hk | - |
dc.identifier.authority | Cheung, WTL=rp02137 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.4161/23723556.2014.983388 | - |
dc.identifier.scopus | eid_2-s2.0-85051533421 | - |
dc.identifier.volume | 2 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | Article no. e983388 | - |
dc.identifier.epage | Article no. e983388 | - |
dc.identifier.eissn | 2372-3556 | - |
dc.identifier.isi | WOS:000218570900039 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 2372-3556 | - |