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- Publisher Website: 10.1097/MNM.0000000000000537
- Scopus: eid_2-s2.0-84965065072
- PMID: 27145439
- WOS: WOS:000382528000006
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Article: Normal range of osteoblastic activity in total hip arthroplasties on single-photon emission computed tomography bone scintigraphy
Title | Normal range of osteoblastic activity in total hip arthroplasties on single-photon emission computed tomography bone scintigraphy |
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Authors | |
Keywords | Bone scintigraphy Hip arthroplasty Osteoblastic activity Single-photon emission computed tomography |
Issue Date | 2016 |
Citation | Nuclear Medicine Communications, 2016, v. 37 n. 9, p. 924-934 How to Cite? |
Abstract | AIM: Knowledge of the normal range of periprosthetic osteoblastic activity around total hip arthroplasties is required for rational diagnosis of complications. The aim of this study was to establish such a normal range for single-photon emission computed tomography (SPECT). Clinical utility of such a range is confident differentiation of normal from abnormal arthroplasties. METHODS: A total of 122 asymptomatic acetabular cups (age: 0-22 years) and 71 femoral stems (age: 0-20 years) were scanned with SPECT/CT. Two acetabular and three femoral activity ratios to normal reference bone were defined [acetabular axial (AA/RA), acetabular coronal (AC/RA), RA=reference acetabulum; femoral calcar (FC/RF), femoral mid-stem (FM/RF), femoral stem tip (FS/RF), RF=reference femur]. Upper cut-off of normal was defined as mean +3 SD (rounded). Two time breakpoints were analysed (12 and 24 months). RESULTS: The upper cut-off for the normal range was 1.0 for AA/RA, 1.5 for AC/RA and 2.2 for all thee of FC/RF, FM/RF and FS/RF. AA/RA, FM/RF and FS/RF showed no statistically significant temporal trends. AC/RA showed stabilization of activity after 12 months and FC/RF after 24 months. CONCLUSION: Measured activity ratios that fall within our normal range are likely to represent normal periprosthetic osteoblastic activity. Measured activity ratios that fall above the upper cut-offs of our normal range are likely to be abnormal. The cut-offs are robust in clinical practice and have utility in discriminating normal from abnormal stabilized arthroplasties where visual interpretation is ambiguous. Elevated AC/RA under 12 months and FC/RF under 24 months may represent normal periprosthetic activity and should be interpreted with caution. |
Persistent Identifier | http://hdl.handle.net/10722/225646 |
ISSN | 2023 Impact Factor: 1.3 2023 SCImago Journal Rankings: 0.374 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jin, S | - |
dc.contributor.author | Boktor, RR | - |
dc.contributor.author | Man, KCK | - |
dc.contributor.author | Pitman, AG | - |
dc.date.accessioned | 2016-05-20T08:09:43Z | - |
dc.date.available | 2016-05-20T08:09:43Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Nuclear Medicine Communications, 2016, v. 37 n. 9, p. 924-934 | - |
dc.identifier.issn | 0143-3636 | - |
dc.identifier.uri | http://hdl.handle.net/10722/225646 | - |
dc.description.abstract | AIM: Knowledge of the normal range of periprosthetic osteoblastic activity around total hip arthroplasties is required for rational diagnosis of complications. The aim of this study was to establish such a normal range for single-photon emission computed tomography (SPECT). Clinical utility of such a range is confident differentiation of normal from abnormal arthroplasties. METHODS: A total of 122 asymptomatic acetabular cups (age: 0-22 years) and 71 femoral stems (age: 0-20 years) were scanned with SPECT/CT. Two acetabular and three femoral activity ratios to normal reference bone were defined [acetabular axial (AA/RA), acetabular coronal (AC/RA), RA=reference acetabulum; femoral calcar (FC/RF), femoral mid-stem (FM/RF), femoral stem tip (FS/RF), RF=reference femur]. Upper cut-off of normal was defined as mean +3 SD (rounded). Two time breakpoints were analysed (12 and 24 months). RESULTS: The upper cut-off for the normal range was 1.0 for AA/RA, 1.5 for AC/RA and 2.2 for all thee of FC/RF, FM/RF and FS/RF. AA/RA, FM/RF and FS/RF showed no statistically significant temporal trends. AC/RA showed stabilization of activity after 12 months and FC/RF after 24 months. CONCLUSION: Measured activity ratios that fall within our normal range are likely to represent normal periprosthetic osteoblastic activity. Measured activity ratios that fall above the upper cut-offs of our normal range are likely to be abnormal. The cut-offs are robust in clinical practice and have utility in discriminating normal from abnormal stabilized arthroplasties where visual interpretation is ambiguous. Elevated AC/RA under 12 months and FC/RF under 24 months may represent normal periprosthetic activity and should be interpreted with caution. | - |
dc.language | eng | - |
dc.relation.ispartof | Nuclear Medicine Communications | - |
dc.subject | Bone scintigraphy | - |
dc.subject | Hip arthroplasty | - |
dc.subject | Osteoblastic activity | - |
dc.subject | Single-photon emission computed tomography | - |
dc.title | Normal range of osteoblastic activity in total hip arthroplasties on single-photon emission computed tomography bone scintigraphy | - |
dc.type | Article | - |
dc.identifier.email | Man, KCK: mkckth@hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/MNM.0000000000000537 | - |
dc.identifier.pmid | 27145439 | - |
dc.identifier.scopus | eid_2-s2.0-84965065072 | - |
dc.identifier.hkuros | 258106 | - |
dc.identifier.volume | 37 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 924 | - |
dc.identifier.epage | 934 | - |
dc.identifier.isi | WOS:000382528000006 | - |
dc.identifier.issnl | 0143-3636 | - |