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Book Chapter: 3',5'-cIMP as potential second messenger in the vascular wall

Title3',5'-cIMP as potential second messenger in the vascular wall
Authors
KeywordsHypoxia
Inosine 3′, 5′-cyclic monophosphate
Magnesium ions
Rho kinase
Soluble guanylyl cyclase
Issue Date2017
PublisherSpringer International Publishing
Citation
3',5'-cIMP as potential second messenger in the vascular wall. In Seifert, R (Ed.), Non-canonical Cyclic Nucleotides, p. 209-228. Cham: Springer International Publishing, 2017 How to Cite?
AbstractTraditionally, only the 3′,5′-cyclic monophosphates of adenosine and guanosine (produced by adenylyl cyclase and guanylyl cyclase, respectively) are regarded as true “second messengers” in the vascular wall, despite the presence of other cyclic nucleotides in different tissues. Among these noncanonical cyclic nucleotides, inosine 3′,5′‐cyclic monophosphate (cIMP) is synthesized by soluble guanylyl cyclase in porcine coronary arteries in response to hypoxia, when the enzyme is activated by endothelium-derived nitric oxide. Its production is associated with augmentation of vascular contraction mediated by stimulation of Rho kinase. Based on these findings, cIMP appears to meet most, if not all, of the criteria required for it to be accepted as a “second messenger,” at least in the vascular wall.
Persistent Identifierhttp://hdl.handle.net/10722/227103
ISSN
2023 SCImago Journal Rankings: 0.303
Series/Report no.Handbook of Experimental Pharmacology ; v. 238

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWS-
dc.contributor.authorGao, Y-
dc.contributor.authorVanhoutte, PMGR-
dc.date.accessioned2016-07-18T09:08:27Z-
dc.date.available2016-07-18T09:08:27Z-
dc.date.issued2017-
dc.identifier.citation3',5'-cIMP as potential second messenger in the vascular wall. In Seifert, R (Ed.), Non-canonical Cyclic Nucleotides, p. 209-228. Cham: Springer International Publishing, 2017-
dc.identifier.issn0171-2004-
dc.identifier.urihttp://hdl.handle.net/10722/227103-
dc.description.abstractTraditionally, only the 3′,5′-cyclic monophosphates of adenosine and guanosine (produced by adenylyl cyclase and guanylyl cyclase, respectively) are regarded as true “second messengers” in the vascular wall, despite the presence of other cyclic nucleotides in different tissues. Among these noncanonical cyclic nucleotides, inosine 3′,5′‐cyclic monophosphate (cIMP) is synthesized by soluble guanylyl cyclase in porcine coronary arteries in response to hypoxia, when the enzyme is activated by endothelium-derived nitric oxide. Its production is associated with augmentation of vascular contraction mediated by stimulation of Rho kinase. Based on these findings, cIMP appears to meet most, if not all, of the criteria required for it to be accepted as a “second messenger,” at least in the vascular wall.-
dc.languageeng-
dc.publisherSpringer International Publishing-
dc.relation.ispartofNon-canonical Cyclic Nucleotides-
dc.relation.ispartofseriesHandbook of Experimental Pharmacology ; v. 238-
dc.subjectHypoxia-
dc.subjectInosine 3′, 5′-cyclic monophosphate-
dc.subjectMagnesium ions-
dc.subjectRho kinase-
dc.subjectSoluble guanylyl cyclase-
dc.title3',5'-cIMP as potential second messenger in the vascular wall-
dc.typeBook_Chapter-
dc.identifier.emailLeung, SWS: swsleung@hku.hk-
dc.identifier.emailVanhoutte, PMGR: vanhoutt@hku.hk-
dc.identifier.authorityLeung, SWS=rp00235-
dc.identifier.authorityVanhoutte, PMGR=rp00238-
dc.identifier.doi10.1007/164_2015_39-
dc.identifier.pmid26721675-
dc.identifier.scopuseid_2-s2.0-85018954178-
dc.identifier.hkuros259268-
dc.identifier.spage209-
dc.identifier.epage228-
dc.identifier.eissn1865-0325-
dc.publisher.placeCham-
dc.identifier.issnl0171-2004-

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