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Article: Is Pilocarpine Effective in Preventing Radiation-Induced Xerostomia? A Systematic Review and Meta-Analysis

TitleIs Pilocarpine Effective in Preventing Radiation-Induced Xerostomia? A Systematic Review and Meta-Analysis
Authors
Issue Date2016
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 2016, v. 94 n. 3, p. 503-511 How to Cite?
AbstractPurpose: To evaluate the efficacy of concomitant administration of pilocarpine on radiation-induced xerostomia in patients with head and neck cancers. Methods and Materials: The PubMed, Web of Science, Cochrane Library, and ClinicalTrials were searched to identify randomized, controlled trials studying the effect of concomitant administration of pilocarpine for radiation-induced xerostomia. Included trials were systematically reviewed, and quantifiable outcomes were pooled for meta-analysis. Outcomes of interest included salivary flow, clinician-rated xerostomia grade, patient-reported xerostomia scoring, quality of life, and adverse effects. Results: Six prospective, randomized, controlled trials in 8 articles were included in this systematic review. The total number of patients was 369 in the pilocarpine group and 367 in the control group. Concomitant administration of pilocarpine during radiation could increase the unstimulated salivary flow rate in a period of 3 to 6 months after treatment, and also reduce the clinician-rated xerostomia grade. Patient-reported xerostomia was not significantly impacted by pilocarpine in the initial 3 months but was superior at 6 months. No significant difference of stimulated salivary flow rate could be confirmed between the 2 arms. Adverse effects of pilocarpine were mild and tolerable. Conclusions: The concomitant administration of pilocarpine during radiation increases unstimulated salivary flow rate and reduces clinician-rated xerostomia grade after radiation. It also relieves patients' xerostomia at 6 months and possibly at 12 months. However, pilocarpine has no effect on stimulated salivary flow rate.
Persistent Identifierhttp://hdl.handle.net/10722/229069
ISSN
2020 Impact Factor: 7.038
2020 SCImago Journal Rankings: 2.117
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, WF-
dc.contributor.authorLiao, GQ-
dc.contributor.authorHakim, SG-
dc.contributor.authorOuyang, DQ-
dc.contributor.authorRingash, J-
dc.contributor.authorSu, Y-
dc.date.accessioned2016-08-23T14:08:48Z-
dc.date.available2016-08-23T14:08:48Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 2016, v. 94 n. 3, p. 503-511-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/229069-
dc.description.abstractPurpose: To evaluate the efficacy of concomitant administration of pilocarpine on radiation-induced xerostomia in patients with head and neck cancers. Methods and Materials: The PubMed, Web of Science, Cochrane Library, and ClinicalTrials were searched to identify randomized, controlled trials studying the effect of concomitant administration of pilocarpine for radiation-induced xerostomia. Included trials were systematically reviewed, and quantifiable outcomes were pooled for meta-analysis. Outcomes of interest included salivary flow, clinician-rated xerostomia grade, patient-reported xerostomia scoring, quality of life, and adverse effects. Results: Six prospective, randomized, controlled trials in 8 articles were included in this systematic review. The total number of patients was 369 in the pilocarpine group and 367 in the control group. Concomitant administration of pilocarpine during radiation could increase the unstimulated salivary flow rate in a period of 3 to 6 months after treatment, and also reduce the clinician-rated xerostomia grade. Patient-reported xerostomia was not significantly impacted by pilocarpine in the initial 3 months but was superior at 6 months. No significant difference of stimulated salivary flow rate could be confirmed between the 2 arms. Adverse effects of pilocarpine were mild and tolerable. Conclusions: The concomitant administration of pilocarpine during radiation increases unstimulated salivary flow rate and reduces clinician-rated xerostomia grade after radiation. It also relieves patients' xerostomia at 6 months and possibly at 12 months. However, pilocarpine has no effect on stimulated salivary flow rate.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physics-
dc.titleIs Pilocarpine Effective in Preventing Radiation-Induced Xerostomia? A Systematic Review and Meta-Analysis-
dc.typeArticle-
dc.identifier.emailSu, Y: richsu@hku.hk-
dc.identifier.authoritySu, Y=rp01916-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2015.11.012-
dc.identifier.pmid26867879-
dc.identifier.scopuseid_2-s2.0-84963755175-
dc.identifier.hkuros260925-
dc.identifier.volume94-
dc.identifier.issue3-
dc.identifier.spage503-
dc.identifier.epage511-
dc.identifier.isiWOS:000370816500011-
dc.publisher.placeUnited States-
dc.identifier.issnl0360-3016-

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