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- Publisher Website: 10.1111/j.1600-051X.2007.01130.x
- Scopus: eid_2-s2.0-34548570177
- PMID: 17711478
- WOS: WOS:000249419800011
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Article: Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: A pilot retrospective study
Title | Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: A pilot retrospective study |
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Authors | |
Keywords | Retrospective study Human Generalized aggressive periodontitis Clinical outcomes Antibiotics Adherence/treatment |
Issue Date | 2007 |
Citation | Journal of Clinical Periodontology, 2007, v. 34, n. 10, p. 897-902 How to Cite? |
Abstract | Aim: The objective of this study was to explore the effect of incomplete adherence to the prescribed antibiotic regimen, amoxicillin and metronidazole, in the non-surgical treatment of generalized aggressive periodontitis (GAP). Methods: This retrospective study included 18 GAP subjects who received a conventional course of full-mouth non-surgical periodontal treatment using machine-driven and hand instruments and an adjunctive course of systemic antibiotics (500 mg amoxicillin and 500 mg metronidazole three times a day for 7 days). Clinical parameters were collected at baseline and at 2 months post-treatment. Self-reported adherence to the prescribed medication regimen was recorded at 2 months. Results: All clinical parameters, except for the mean clinical attachment level (CAL) in sites with initial probing pocket depth (PPD) ≤3 mm, improved at 2 months in all subjects. PPD reduction was 3.7 mm [95% confidence interval (CI) 3.2, 4.3 mm] in deep pockets (≥7 mm) and 2.2 mm (95% CI 1.9, 2.4 mm) in moderate pockets (4-6 mm), while CAL gain was 2.2 mm (95% CI 1.7, 2.6 mm) and 1.2 mm (95% CI 0.8, 1.5 mm), respectively. However, only 11 subjects (61.1%) reported full adherence to the medication. In deep pockets (≥7 mm), the difference between an adherent and non-adherent/partially adherent subject was 0.9 mm (95% CI 0.1, 1.7 mm, ancova, p=0.027) in PPD reduction and 0.8 mm (95% CI -0.2, 1.9, p=0.129) in CAL gain at 2 months. In moderate pockets (4-6 mm) this difference was smaller in magnitude: 0.4 mm (95% CI 0.1, 0.9 mm, p=0.036) in PPD reduction and 0.2 mm (95% CI -0.3, 0.9 mm, p=0.332) in CAL gain. Conclusions: Within the limits of this design, these data suggest that incomplete adherence to a 7-day adjunctive course of systemic metronidazole and amoxicillin is associated with decreased clinical outcomes in subjects with generalized aggressive periodontitis. © 2007 Blackwell Munksgaard. |
Persistent Identifier | http://hdl.handle.net/10722/230789 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 2.249 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Guerrero, Adrian | - |
dc.contributor.author | Echeverría, Jose J. | - |
dc.contributor.author | Tonetti, Maurizio S. | - |
dc.date.accessioned | 2016-09-01T06:06:48Z | - |
dc.date.available | 2016-09-01T06:06:48Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Clinical Periodontology, 2007, v. 34, n. 10, p. 897-902 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230789 | - |
dc.description.abstract | Aim: The objective of this study was to explore the effect of incomplete adherence to the prescribed antibiotic regimen, amoxicillin and metronidazole, in the non-surgical treatment of generalized aggressive periodontitis (GAP). Methods: This retrospective study included 18 GAP subjects who received a conventional course of full-mouth non-surgical periodontal treatment using machine-driven and hand instruments and an adjunctive course of systemic antibiotics (500 mg amoxicillin and 500 mg metronidazole three times a day for 7 days). Clinical parameters were collected at baseline and at 2 months post-treatment. Self-reported adherence to the prescribed medication regimen was recorded at 2 months. Results: All clinical parameters, except for the mean clinical attachment level (CAL) in sites with initial probing pocket depth (PPD) ≤3 mm, improved at 2 months in all subjects. PPD reduction was 3.7 mm [95% confidence interval (CI) 3.2, 4.3 mm] in deep pockets (≥7 mm) and 2.2 mm (95% CI 1.9, 2.4 mm) in moderate pockets (4-6 mm), while CAL gain was 2.2 mm (95% CI 1.7, 2.6 mm) and 1.2 mm (95% CI 0.8, 1.5 mm), respectively. However, only 11 subjects (61.1%) reported full adherence to the medication. In deep pockets (≥7 mm), the difference between an adherent and non-adherent/partially adherent subject was 0.9 mm (95% CI 0.1, 1.7 mm, ancova, p=0.027) in PPD reduction and 0.8 mm (95% CI -0.2, 1.9, p=0.129) in CAL gain at 2 months. In moderate pockets (4-6 mm) this difference was smaller in magnitude: 0.4 mm (95% CI 0.1, 0.9 mm, p=0.036) in PPD reduction and 0.2 mm (95% CI -0.3, 0.9 mm, p=0.332) in CAL gain. Conclusions: Within the limits of this design, these data suggest that incomplete adherence to a 7-day adjunctive course of systemic metronidazole and amoxicillin is associated with decreased clinical outcomes in subjects with generalized aggressive periodontitis. © 2007 Blackwell Munksgaard. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Periodontology | - |
dc.subject | Retrospective study | - |
dc.subject | Human | - |
dc.subject | Generalized aggressive periodontitis | - |
dc.subject | Clinical outcomes | - |
dc.subject | Antibiotics | - |
dc.subject | Adherence/treatment | - |
dc.title | Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: A pilot retrospective study | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1600-051X.2007.01130.x | - |
dc.identifier.pmid | 17711478 | - |
dc.identifier.scopus | eid_2-s2.0-34548570177 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 897 | - |
dc.identifier.epage | 902 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.isi | WOS:000249419800011 | - |
dc.identifier.issnl | 0303-6979 | - |