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- Publisher Website: 10.1111/j.1600-051X.2010.01632.x
- Scopus: eid_2-s2.0-78650383157
- PMID: 21062335
- WOS: WOS:000285391200006
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Article: Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: A randomized controlled clinical trial
Title | Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: A randomized controlled clinical trial |
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Authors | |
Keywords | human generalized aggressive periodontitis randomized controlled clinical trial treatment antibiotics |
Issue Date | 2011 |
Citation | Journal of Clinical Periodontology, 2011, v. 38, n. 1, p. 43-49 How to Cite? |
Abstract | Background: Previously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non-surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re-treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group. Methods: Thirty-eight of 41 subjects, from the initial 6-month trial, completed the second phase, re-treatment of sites with remaining pockets 5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline). Results: Patients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re-treatment. In deep pockets (7 mm), the mean difference was 0.9 mm (p=0.003) and in moderate pockets (4-6 mm) it was 0.4 mm (p=0.036). For pockets converting from 5 to 4 mm, this was 83% compared with 67% (p=0.041) and pockets converting from 4 to 3 mm was 63% compared with 49% (p=0.297). Conclusions: At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re-treatment. © 2010 John Wiley & Sons A/S. |
Persistent Identifier | http://hdl.handle.net/10722/230860 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 2.249 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Griffiths, Gareth S. | - |
dc.contributor.author | Ayob, Rasidah | - |
dc.contributor.author | Guerrero, Adrian | - |
dc.contributor.author | Nibali, Luigi | - |
dc.contributor.author | Suvan, Jean | - |
dc.contributor.author | Moles, David R. | - |
dc.contributor.author | Tonetti, Maurizio S. | - |
dc.date.accessioned | 2016-09-01T06:06:58Z | - |
dc.date.available | 2016-09-01T06:06:58Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Journal of Clinical Periodontology, 2011, v. 38, n. 1, p. 43-49 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230860 | - |
dc.description.abstract | Background: Previously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non-surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re-treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group. Methods: Thirty-eight of 41 subjects, from the initial 6-month trial, completed the second phase, re-treatment of sites with remaining pockets 5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline). Results: Patients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re-treatment. In deep pockets (7 mm), the mean difference was 0.9 mm (p=0.003) and in moderate pockets (4-6 mm) it was 0.4 mm (p=0.036). For pockets converting from 5 to 4 mm, this was 83% compared with 67% (p=0.041) and pockets converting from 4 to 3 mm was 63% compared with 49% (p=0.297). Conclusions: At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re-treatment. © 2010 John Wiley & Sons A/S. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Periodontology | - |
dc.subject | human | - |
dc.subject | generalized aggressive periodontitis | - |
dc.subject | randomized controlled clinical trial | - |
dc.subject | treatment | - |
dc.subject | antibiotics | - |
dc.title | Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: A randomized controlled clinical trial | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1600-051X.2010.01632.x | - |
dc.identifier.pmid | 21062335 | - |
dc.identifier.scopus | eid_2-s2.0-78650383157 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 43 | - |
dc.identifier.epage | 49 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.isi | WOS:000285391200006 | - |
dc.identifier.issnl | 0303-6979 | - |