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- Publisher Website: 10.1111/jcpe.12299
- Scopus: eid_2-s2.0-84964253493
- PMID: 25139116
- WOS: WOS:000344477400007
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Article: Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: An exploratory analysis from a randomized controlled clinical trial
Title | Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: An exploratory analysis from a randomized controlled clinical trial |
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Authors | |
Keywords | Exploratory analysis Treatment Human Generalized aggressive periodontitis Antimicrobials Aggregatibacter actinomycetemcomitans |
Issue Date | 2014 |
Citation | Journal of Clinical Periodontology, 2014, v. 41, n. 11, p. 1080-1089 How to Cite? |
Abstract | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Aim: To explore whether subjects harbouring A. actinomycetemcomitans, P. gingivalis or T. forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP). Material and Methods: Forty one subjects were included in this 6-month randomized placebo-controlled clinical trial using a 7-day course of systemic AMX-MET or placebo as adjuncts to non-surgical periodontal therapy. Clinical and microbiological parameters were collected at baseline, 2 and 6 months after treatment. Microbiological cultures were processed for pooled subgingival samples and identities of isolates were determined by PCR for A. actinomycetemcomitans, P. gingivalis and T. forsythia Results: At 6 months, the test treatment resulted in significant additional improvements in the primary outcome variable compared to placebo, and the effect of the adjunctive antimicrobials was not modified by the baseline microbiological status in the primary analysis. However, secondary exploratory subgroup analyses showed improved clinical outcomes in subjects harbouring |
Persistent Identifier | http://hdl.handle.net/10722/231032 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 2.249 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Guerrero, Adrián | - |
dc.contributor.author | Nibali, Luigi | - |
dc.contributor.author | Lambertenghi, Roberta | - |
dc.contributor.author | Ready, Derren | - |
dc.contributor.author | Suvan, Jean | - |
dc.contributor.author | Griffiths, Gareth S. | - |
dc.contributor.author | Wilson, Michael | - |
dc.contributor.author | Tonetti, Maurizio S. | - |
dc.date.accessioned | 2016-09-01T06:07:26Z | - |
dc.date.available | 2016-09-01T06:07:26Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Clinical Periodontology, 2014, v. 41, n. 11, p. 1080-1089 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | http://hdl.handle.net/10722/231032 | - |
dc.description.abstract | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Aim: To explore whether subjects harbouring A. actinomycetemcomitans, P. gingivalis or T. forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP). Material and Methods: Forty one subjects were included in this 6-month randomized placebo-controlled clinical trial using a 7-day course of systemic AMX-MET or placebo as adjuncts to non-surgical periodontal therapy. Clinical and microbiological parameters were collected at baseline, 2 and 6 months after treatment. Microbiological cultures were processed for pooled subgingival samples and identities of isolates were determined by PCR for A. actinomycetemcomitans, P. gingivalis and T. forsythia Results: At 6 months, the test treatment resulted in significant additional improvements in the primary outcome variable compared to placebo, and the effect of the adjunctive antimicrobials was not modified by the baseline microbiological status in the primary analysis. However, secondary exploratory subgroup analyses showed improved clinical outcomes in subjects harbouring | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Periodontology | - |
dc.subject | Exploratory analysis | - |
dc.subject | Treatment | - |
dc.subject | Human | - |
dc.subject | Generalized aggressive periodontitis | - |
dc.subject | Antimicrobials | - |
dc.subject | Aggregatibacter actinomycetemcomitans | - |
dc.title | Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: An exploratory analysis from a randomized controlled clinical trial | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/jcpe.12299 | - |
dc.identifier.pmid | 25139116 | - |
dc.identifier.scopus | eid_2-s2.0-84964253493 | - |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 1080 | - |
dc.identifier.epage | 1089 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.isi | WOS:000344477400007 | - |
dc.identifier.issnl | 0303-6979 | - |