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- Publisher Website: 10.1093/infdis/jiv380
- Scopus: eid_2-s2.0-84964848410
- PMID: 26203058
- WOS: WOS:000374186000006
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Article: Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
Title | Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways |
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Authors | |
Keywords | MERS-CoV T lymphocytes Apoptosis Caspase Tonsil Spleen Marmosets |
Issue Date | 2016 |
Publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/ |
Citation | Journal of Infectious Diseases, 2016, v. 213 n. 6, p. 904-914 How to Cite? |
Abstract | Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV–infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3+ T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus. |
Persistent Identifier | http://hdl.handle.net/10722/231185 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.387 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chu, H | - |
dc.contributor.author | Zhou, J | - |
dc.contributor.author | Wong, HYB | - |
dc.contributor.author | Li, C | - |
dc.contributor.author | Chan, JFW | - |
dc.contributor.author | Cheng, Z | - |
dc.contributor.author | Yang, D | - |
dc.contributor.author | Wang, D | - |
dc.contributor.author | Lee, CY | - |
dc.contributor.author | Li, C | - |
dc.contributor.author | Yeung, ML | - |
dc.contributor.author | Cai, J | - |
dc.contributor.author | Chan, HYI | - |
dc.contributor.author | Ho, WK | - |
dc.contributor.author | To, KKW | - |
dc.contributor.author | Zheng, B | - |
dc.contributor.author | Yao, Y | - |
dc.contributor.author | Qin, C | - |
dc.contributor.author | Yuen, KY | - |
dc.date.accessioned | 2016-09-20T05:21:16Z | - |
dc.date.available | 2016-09-20T05:21:16Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Infectious Diseases, 2016, v. 213 n. 6, p. 904-914 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/10722/231185 | - |
dc.description.abstract | Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV–infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3+ T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/ | - |
dc.relation.ispartof | Journal of Infectious Diseases | - |
dc.subject | MERS-CoV | - |
dc.subject | T lymphocytes | - |
dc.subject | Apoptosis | - |
dc.subject | Caspase | - |
dc.subject | Tonsil | - |
dc.subject | Spleen | - |
dc.subject | Marmosets | - |
dc.title | Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways | - |
dc.type | Article | - |
dc.identifier.email | Chu, H: hinchu@hku.hk | - |
dc.identifier.email | Zhou, J: jiezhou@hku.hk | - |
dc.identifier.email | Li, C: licun@HKUCC-COM.hku.hk | - |
dc.identifier.email | Chan, JFW: jfwchan@hku.hk | - |
dc.identifier.email | Yang, D: dongfang@hku.hk | - |
dc.identifier.email | Wang, D: wdfly@HKUCC-COM.hku.hk | - |
dc.identifier.email | Yeung, ML: pmlyeung@hku.hk | - |
dc.identifier.email | Cai, J: caijuice@hku.hk | - |
dc.identifier.email | Chan, HYI: ivyhchan@hku.hk | - |
dc.identifier.email | Ho, WK: wkho@hkucc.hku.hk | - |
dc.identifier.email | To, KKW: kelvinto@hkucc.hku.hk | - |
dc.identifier.email | Zheng, B: bzheng@hkucc.hku.hk | - |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | - |
dc.identifier.authority | Chu, H=rp02125 | - |
dc.identifier.authority | Zhou, J=rp01412 | - |
dc.identifier.authority | Chan, JFW=rp01736 | - |
dc.identifier.authority | Yeung, ML=rp01402 | - |
dc.identifier.authority | To, KKW=rp01384 | - |
dc.identifier.authority | Zheng, B=rp00353 | - |
dc.identifier.authority | Yuen, KY=rp00366 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/infdis/jiv380 | - |
dc.identifier.pmid | 26203058 | - |
dc.identifier.pmcid | PMC7107330 | - |
dc.identifier.scopus | eid_2-s2.0-84964848410 | - |
dc.identifier.hkuros | 266249 | - |
dc.identifier.volume | 213 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 904 | - |
dc.identifier.epage | 914 | - |
dc.identifier.eissn | 1537-6613 | - |
dc.identifier.isi | WOS:000374186000006 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-1899 | - |