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Article: The role of heme oxygenase-1 in the protection of chronic intermittent hypoxia-induced lung injury in vivo
Title | The role of heme oxygenase-1 in the protection of chronic intermittent hypoxia-induced lung injury in vivo 慢性间歇性低氧导致鼠肺部损伤的机制及血红素加氧酶-1的保护作用 |
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Authors | |
Keywords | Sleep apnea syndrome (睡眠呼吸暂停综合征) Obstructive Pulmonary disease (阻塞性肺疾病) Chronic obstructive (慢性阻塞性) Inflammatory effect (炎症反应) Cell apoptosis (细胞凋亡) |
Issue Date | 2015 |
Publisher | Zhong Hua Yi Xue Hui Za Zhi She (中华医学会杂志社). The Journal's web site is located at http://lung.org.cn/ |
Citation | Chinese journal of tuberculosis and respiratory diseases, 2015, v. 38 n. 07, p. 516-519 How to Cite? 中华结核和呼吸杂志, 2015, v. 38 n. 07, p. 516-519 How to Cite? |
Abstract | 目的 观察慢性间歇低氧(CIH)对大鼠肺脏局部炎症反应以及肺泡结构的影响,探讨药物诱导血红素加氧酶-1(HO-1)在此过程中的干预效果.方法 Sprague-Dawley雄性大鼠24只,按随机数字表法分为常氧对照组、CIH组、常氧+hemin干预组(hemin组)和CIH+hemin干预组(CIH+ hemin组),每组6只.CIH组大鼠予间歇低氧环境中(4 min10% +2 min21% 02,8 h/d,共6周),对照组大鼠置于常氧环境中.利用腹腔注射hemin(4 mg/kg)诱导HO-1表达,IN组及CIH组腹腔注射等体积生理盐水.采用western blot检测大鼠肺脏HO-1及cleaved caspase3表达水平,ELISA检测大鼠肺脏局部炎症因子中性粒细胞化学趋化因子-1(CINC-1)、IL-6、肿瘤坏死因子-α(TNF-α)和单核细胞趋化蛋白-1(MCP-1)的表达水平,使用HE染色观察大鼠肺脏病理改变.结果 为期6周的CIH可明显升高肺脏炎症因子TNF-α[(2.20 ±0.10) vs (1.80±0.08) ng/ml]、IL-6[(0.87 ±0.05) vs(0.52 ±0.05) ng/ml]、CINC-1[(66 ±6) vs (39 ±5) pg/ml]和MCP-1[(2.20土0.09)vs(1.40±0.10) ng/ml]以及cleaved caspase3表达(均P<0.05),hemin可明显抑制由于CIH诱导的肺脏炎症因子[(TNF-α:(1.60±0.20) ng/ml,IL-6:(0.60±0.07) ng/ml,CINC-1:(45±6) pg/ml,MCP-1:(1.80 ±0.10) ng/ml,均P<0.05]水平增高以及cleaved caspase3表达(P<0.01),肺脏HO-1表达明显升高.hemin可进一步增加CIH下肺脏HO-1的表达水平.CIH导致肺泡结构损伤,而hemin诱导的HO-1升高可明显抑制由于CIH诱导的肺脏病理改变.结论 CIH可导致肺脏局部炎症因子表达升高,细胞凋亡及肺泡结构破坏,药物诱导HO-1升高可抑制CIH诱导的局部炎症反应和细胞凋亡,逆转肺泡结构损伤,表明CIH对肺脏的损伤作用及HO-1的保护功能. |
Persistent Identifier | http://hdl.handle.net/10722/232029 |
ISSN | 2023 SCImago Journal Rankings: 0.173 |
DC Field | Value | Language |
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dc.contributor.author | Han, Q | - |
dc.contributor.author | Li, G | - |
dc.contributor.author | Mak, JCW | - |
dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Ip, MSM | - |
dc.contributor.author | Zhang, N | - |
dc.creator | csl 161130 | - |
dc.date.accessioned | 2016-09-20T05:27:06Z | - |
dc.date.available | 2016-09-20T05:27:06Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Chinese journal of tuberculosis and respiratory diseases, 2015, v. 38 n. 07, p. 516-519 | - |
dc.identifier.citation | 中华结核和呼吸杂志, 2015, v. 38 n. 07, p. 516-519 | - |
dc.identifier.issn | 1001-0939 | - |
dc.identifier.uri | http://hdl.handle.net/10722/232029 | - |
dc.description.abstract | 目的 观察慢性间歇低氧(CIH)对大鼠肺脏局部炎症反应以及肺泡结构的影响,探讨药物诱导血红素加氧酶-1(HO-1)在此过程中的干预效果.方法 Sprague-Dawley雄性大鼠24只,按随机数字表法分为常氧对照组、CIH组、常氧+hemin干预组(hemin组)和CIH+hemin干预组(CIH+ hemin组),每组6只.CIH组大鼠予间歇低氧环境中(4 min10% +2 min21% 02,8 h/d,共6周),对照组大鼠置于常氧环境中.利用腹腔注射hemin(4 mg/kg)诱导HO-1表达,IN组及CIH组腹腔注射等体积生理盐水.采用western blot检测大鼠肺脏HO-1及cleaved caspase3表达水平,ELISA检测大鼠肺脏局部炎症因子中性粒细胞化学趋化因子-1(CINC-1)、IL-6、肿瘤坏死因子-α(TNF-α)和单核细胞趋化蛋白-1(MCP-1)的表达水平,使用HE染色观察大鼠肺脏病理改变.结果 为期6周的CIH可明显升高肺脏炎症因子TNF-α[(2.20 ±0.10) vs (1.80±0.08) ng/ml]、IL-6[(0.87 ±0.05) vs(0.52 ±0.05) ng/ml]、CINC-1[(66 ±6) vs (39 ±5) pg/ml]和MCP-1[(2.20土0.09)vs(1.40±0.10) ng/ml]以及cleaved caspase3表达(均P<0.05),hemin可明显抑制由于CIH诱导的肺脏炎症因子[(TNF-α:(1.60±0.20) ng/ml,IL-6:(0.60±0.07) ng/ml,CINC-1:(45±6) pg/ml,MCP-1:(1.80 ±0.10) ng/ml,均P<0.05]水平增高以及cleaved caspase3表达(P<0.01),肺脏HO-1表达明显升高.hemin可进一步增加CIH下肺脏HO-1的表达水平.CIH导致肺泡结构损伤,而hemin诱导的HO-1升高可明显抑制由于CIH诱导的肺脏病理改变.结论 CIH可导致肺脏局部炎症因子表达升高,细胞凋亡及肺泡结构破坏,药物诱导HO-1升高可抑制CIH诱导的局部炎症反应和细胞凋亡,逆转肺泡结构损伤,表明CIH对肺脏的损伤作用及HO-1的保护功能. | - |
dc.language | chi | - |
dc.publisher | Zhong Hua Yi Xue Hui Za Zhi She (中华医学会杂志社). The Journal's web site is located at http://lung.org.cn/ | - |
dc.relation.ispartof | Chinese journal of tuberculosis and respiratory diseases | - |
dc.relation.ispartof | 中华结核和呼吸杂志 | - |
dc.subject | Sleep apnea syndrome (睡眠呼吸暂停综合征) | - |
dc.subject | Obstructive Pulmonary disease (阻塞性肺疾病) | - |
dc.subject | Chronic obstructive (慢性阻塞性) | - |
dc.subject | Inflammatory effect (炎症反应) | - |
dc.subject | Cell apoptosis (细胞凋亡) | - |
dc.title | The role of heme oxygenase-1 in the protection of chronic intermittent hypoxia-induced lung injury in vivo | - |
dc.title | 慢性间歇性低氧导致鼠肺部损伤的机制及血红素加氧酶-1的保护作用 | - |
dc.type | Article | - |
dc.identifier.email | Mak, JCW: judithmak@hku.hk | - |
dc.identifier.email | Zhang, Y: zyl1999@hku.hk | - |
dc.identifier.email | Ip, MSM: msmip@hku.hk | - |
dc.identifier.authority | Han, Q=rp02224 | - |
dc.identifier.authority | Li, G=rp02224 | - |
dc.identifier.authority | Mak, JCW=rp00352 | - |
dc.identifier.authority | Ip, MSM=rp00347 | - |
dc.identifier.authority | Zhang, N=rp02224 | - |
dc.identifier.doi | 10.3760/cma.j.issn.1001-0939.2015.07.011 | - |
dc.identifier.hkuros | 264387 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 07 | - |
dc.identifier.spage | 516 | - |
dc.identifier.epage | 519 | - |
dc.publisher.place | Beijing (北京) | - |
dc.identifier.issnl | 1001-0939 | - |