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- Publisher Website: 10.1038/cmi.2015.82
- Scopus: eid_2-s2.0-84966343988
- PMID: 26388237
- WOS: WOS:000375416500014
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Article: Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis
Title | Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis |
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Authors | |
Keywords | CIA Olfactory ecto-mesenchymal stem cells Treg cell |
Issue Date | 2016 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/cmi/index.html |
Citation | Cellular & Molecular Immunology, 2016, v. 13 n. 3, p. 401-408 How to Cite? |
Abstract | Recent studies have identified olfactory ecto-mesenchymal stem cells (OE-MSCs) as a new type of resident stem cell in the olfactory lamina propria. However, it remains unclear whether OE-MSCs possess any immunoregulatory functions. In this study, we found that mouse OE-MSCs expressed higher transforming growth factor-beta and interleukin-10 levels than bone marrow-derived MSCs. In culture, OE-MSCs exerted their immunosuppressive capacity via directly suppressing effector T-cell proliferation and increasing regulatory T (Treg) cell expansion. In mice with collagen-induced arthritis, adoptive transfer of OE-MSCs markedly suppressed arthritis onset and disease severity, which was accompanied by increased Treg cells and reduced Th1/Th17 cell responses in vivo. Taken together, our findings identified a novel function of OE-MSCs in regulating T-cell responses, indicating that OE-MSCs may represent a new cell therapy for the treatment of rheumatoid arthritis and other autoimmune diseases. |
Persistent Identifier | http://hdl.handle.net/10722/232155 |
ISSN | 2023 Impact Factor: 21.8 2023 SCImago Journal Rankings: 4.838 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rui, K | - |
dc.contributor.author | Zhang, Z | - |
dc.contributor.author | Tian, J | - |
dc.contributor.author | Lin, X | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Ma, J | - |
dc.contributor.author | Tang, X | - |
dc.contributor.author | Xu, H | - |
dc.contributor.author | Lu, L | - |
dc.contributor.author | Wang, S | - |
dc.date.accessioned | 2016-09-20T05:28:06Z | - |
dc.date.available | 2016-09-20T05:28:06Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Cellular & Molecular Immunology, 2016, v. 13 n. 3, p. 401-408 | - |
dc.identifier.issn | 1672-7681 | - |
dc.identifier.uri | http://hdl.handle.net/10722/232155 | - |
dc.description.abstract | Recent studies have identified olfactory ecto-mesenchymal stem cells (OE-MSCs) as a new type of resident stem cell in the olfactory lamina propria. However, it remains unclear whether OE-MSCs possess any immunoregulatory functions. In this study, we found that mouse OE-MSCs expressed higher transforming growth factor-beta and interleukin-10 levels than bone marrow-derived MSCs. In culture, OE-MSCs exerted their immunosuppressive capacity via directly suppressing effector T-cell proliferation and increasing regulatory T (Treg) cell expansion. In mice with collagen-induced arthritis, adoptive transfer of OE-MSCs markedly suppressed arthritis onset and disease severity, which was accompanied by increased Treg cells and reduced Th1/Th17 cell responses in vivo. Taken together, our findings identified a novel function of OE-MSCs in regulating T-cell responses, indicating that OE-MSCs may represent a new cell therapy for the treatment of rheumatoid arthritis and other autoimmune diseases. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/cmi/index.html | - |
dc.relation.ispartof | Cellular & Molecular Immunology | - |
dc.subject | CIA | - |
dc.subject | Olfactory ecto-mesenchymal stem cells | - |
dc.subject | Treg cell | - |
dc.title | Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis | - |
dc.type | Article | - |
dc.identifier.email | Lin, X: linxiang@hku.hk | - |
dc.identifier.email | Wang, X: xiaohuiwang@hku.hk | - |
dc.identifier.email | Lu, L: liweilu@hkucc.hku.hk | - |
dc.identifier.authority | Lin, X=rp02623 | - |
dc.identifier.authority | Wang, X=rp02664 | - |
dc.identifier.authority | Lu, L=rp00477 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1038/cmi.2015.82 | - |
dc.identifier.pmid | 26388237 | - |
dc.identifier.pmcid | PMC4856806 | - |
dc.identifier.scopus | eid_2-s2.0-84966343988 | - |
dc.identifier.hkuros | 264668 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 401 | - |
dc.identifier.epage | 408 | - |
dc.identifier.isi | WOS:000375416500014 | - |
dc.publisher.place | China | - |
dc.identifier.issnl | 1672-7681 | - |