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Article: Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor
| Title | Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor |
|---|---|
| Authors | |
| Issue Date | 2016 |
| Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ |
| Citation | Hong Kong Medical Journal, 2016, v. 22 n. 3, suppl 4, p. 43-47 How to Cite? |
| Abstract | Key Messages
1. The natural COOH-terminal truncated HBx was more frequently detected in hepatocellular carcinoma (HCC) in male than female patients.
2. There was no significant clinicopathological correlation with the HBx status or remarkable changes in androgen receptor (AR) expression in the presence of different truncated HBx mutants compared with full-length HBx.
3. Lower expression of AR was associated with more aggressive tumour phenotype and a higher metastatic potential of HCC. |
| Persistent Identifier | http://hdl.handle.net/10722/232160 |
| ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chiu, YT | - |
| dc.contributor.author | Ng, IOL | - |
| dc.date.accessioned | 2016-09-20T05:28:08Z | - |
| dc.date.available | 2016-09-20T05:28:08Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.citation | Hong Kong Medical Journal, 2016, v. 22 n. 3, suppl 4, p. 43-47 | - |
| dc.identifier.issn | 1024-2708 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/232160 | - |
| dc.description.abstract | Key Messages 1. The natural COOH-terminal truncated HBx was more frequently detected in hepatocellular carcinoma (HCC) in male than female patients. 2. There was no significant clinicopathological correlation with the HBx status or remarkable changes in androgen receptor (AR) expression in the presence of different truncated HBx mutants compared with full-length HBx. 3. Lower expression of AR was associated with more aggressive tumour phenotype and a higher metastatic potential of HCC. | - |
| dc.language | eng | - |
| dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ | - |
| dc.relation.ispartof | Hong Kong Medical Journal | - |
| dc.rights | Hong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press. | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.title | Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor | - |
| dc.type | Article | - |
| dc.identifier.email | Chiu, YT: ellechiu@pathology.hku.hk | - |
| dc.identifier.email | Ng, IOL: iolng@hku.hk | - |
| dc.identifier.authority | Ng, IOL=rp00335 | - |
| dc.description.nature | published_or_final_version | - |
| dc.identifier.pmid | 27390010 | - |
| dc.identifier.hkuros | 264753 | - |
| dc.identifier.volume | 22 | - |
| dc.identifier.issue | 3, suppl 4 | - |
| dc.identifier.spage | 43 | - |
| dc.identifier.epage | 47 | - |
| dc.publisher.place | Hong Kong | - |
| dc.identifier.issnl | 1024-2708 | - |