Electrospun shape memory scaffolds for bone tissue engineering

Abstract

INTRODUCTION: Emulsion electrospinning is extensively used to make tissue engineering scaffolds with the capability of delivering bioactive agents such as growth factors [1]. Bone morphogenetic protein-2 (BMP-2) is a potent growth factor for osteogenesis. On the other hand, shape memory polymers (SMPs) have attracted great attention in tissue engineering[2]. An SMP device can be packed into a temporary shape with a much reduced size. After implantation through a narrow path, the device may recover to its larger and permanent shape upon specific stimulus. Another important issue is electrospinning of thick, 3D scaffolds. This study investigated electrospinning of a shape memory polymer, poly(D,L-lactide-co-trimethylene carbonate) P(DLLA-co-TMC), into thermo-responsive scaffolds. An auxiliary process was studied for facilitating the formation of thick scaffolds ...