Coaxial electrospray for cell encapsulation and delivery in cell-based tissue engineering

Abstract

INTRODUCTION: For human body tissue regeneration, different approaches, including scaffold-based[1], growth factor-based[2] and cell-based tissue engineering[3], are explored. In cell-based tissue engineering, developing appropriate vehicles for cell encapsulation and delivery is highly important. The process of cell encapsulation must be cell-friendly for achieving high cell viability. Moreover, for microspherical delivery vehicles, the diameter of cell-encapsulated microspheres is a critical factor. The diameter should not be too small or too large. Degradation properties of polymers for microspheres are another important factor for cell delivery. Coaxial electrospray can produce core-shell structured microspheres and hence was investigated in this study for the encapsulation and delivery of cells ...