Triggered release of anticancer drug and theranostics from microspherical vehicles made by coaxial electrospray

Abstract

INTRODUCTION: Current cancer treatment includes chemotherapy, radiotherapy, and surgery. But they have respective limitations. Developing novel theranostics, the nanodevices for cancer detection and treatment, is a major focus for nanotechnology in oncology[1]. Gold nanoparticles (AuNPs) are attractive for theranostics due to their unique properties, including surface enhanced Raman scattering (SERS)[2], which can provide high-sensitivity signals for cancer detection. Composite NPs based on AuNP can be made as drug carriers but the amount of drug incorporated in this type of theranostics is limited. Furthermore, for some applications, timed release of theranostics and drug is needed. This study investigated the encapsulation and release of theranostics and drug in microspherical delivery vehicles ...