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Conference Paper: Applicability and Psychometric Evaluation of Utility and Cancer-Specific Health-Related Quality of Life Measures in patients with Incidental Thyroid Nodules
Title | Applicability and Psychometric Evaluation of Utility and Cancer-Specific Health-Related Quality of Life Measures in patients with Incidental Thyroid Nodules |
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Authors | |
Issue Date | 2016 |
Publisher | Sage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=263 |
Citation | The 16th Biennial European Conference of the Society for Medical Decision Making (SMDM-European Conference 2016), London, UK., 12-16 June 2016. In Medical Decision Making, 2016, v. 36 n. 7, p. E510-E511 How to Cite? |
Abstract | PURPOSE: The aim of this study was to examine the acceptability, validity and reliability of utility measures and cancer-specific health-related quality of life (HRQOL) in Chinese patients diagnosed with incidental thyroid nodules. METHOD(s): Data from a randomized controlled trial (ClinicalTrials.gov Identifier: NCT02398721) of 314 patients diagnosed with incidental thyroid nodules were utilized for this psychometric evaluation of HRQOL measurement. Three HRQOL questionnaires, cancer-specific Functional Assessment of Cancer Therapy-general (FACT-G) and generic 12-item Short Form Health Survey (SF-12v2) and 6-item Short Form Health Survey (SF-6D), were administered through face-to-face interviews at both baseline and 2-week after baseline. Responses to SF-6D were transformed to SF-6D utility scores using Hong Kong standard gamble value set. Construct validity was determined by evaluating the extent to overlap SF-12v2 dimensions across HRQOL instruments by Spearman rank correlation. Internal consistency and 2-week test-retest reliability was assessed using Cronbach’s α coefficient and intra-class correlation coefficient, respectively. RESULT(s): No significant (>15%) floor and ceiling effects were observed for FACT-G subscale and total scores. The SF-6D utility scores and FACT-G subscale scores had a moderate Spearman rank correlation with the corresponding SF-12v2 domain score that conceptually measures the similar construct providing evidence for adequate construct validity. Internal consistency of the FACT-G subscales and total scales were acceptable (α: 0.639-0.850) for all subscales aside from the Emotional well-being subscale (α: 0.581). The HRQOL and utility scores showed excellent test-retest reliability (range: 0.758-0.858). CONCLUSION(s): The SF-6D utility score and cancer-specific FACT-G questionnaire appears to be a valid and reliable measure to assess the HRQOL of Chinese patients diagnosed with incidental thyroid nodules, and thus evaluate the treatment response to those patients. |
Description | Poster Session 3: no. PS3-20 |
Persistent Identifier | http://hdl.handle.net/10722/233623 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.165 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, CKH | - |
dc.contributor.author | Lang, HHB | - |
dc.date.accessioned | 2016-09-20T05:38:02Z | - |
dc.date.available | 2016-09-20T05:38:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | The 16th Biennial European Conference of the Society for Medical Decision Making (SMDM-European Conference 2016), London, UK., 12-16 June 2016. In Medical Decision Making, 2016, v. 36 n. 7, p. E510-E511 | - |
dc.identifier.issn | 0272-989X | - |
dc.identifier.uri | http://hdl.handle.net/10722/233623 | - |
dc.description | Poster Session 3: no. PS3-20 | - |
dc.description.abstract | PURPOSE: The aim of this study was to examine the acceptability, validity and reliability of utility measures and cancer-specific health-related quality of life (HRQOL) in Chinese patients diagnosed with incidental thyroid nodules. METHOD(s): Data from a randomized controlled trial (ClinicalTrials.gov Identifier: NCT02398721) of 314 patients diagnosed with incidental thyroid nodules were utilized for this psychometric evaluation of HRQOL measurement. Three HRQOL questionnaires, cancer-specific Functional Assessment of Cancer Therapy-general (FACT-G) and generic 12-item Short Form Health Survey (SF-12v2) and 6-item Short Form Health Survey (SF-6D), were administered through face-to-face interviews at both baseline and 2-week after baseline. Responses to SF-6D were transformed to SF-6D utility scores using Hong Kong standard gamble value set. Construct validity was determined by evaluating the extent to overlap SF-12v2 dimensions across HRQOL instruments by Spearman rank correlation. Internal consistency and 2-week test-retest reliability was assessed using Cronbach’s α coefficient and intra-class correlation coefficient, respectively. RESULT(s): No significant (>15%) floor and ceiling effects were observed for FACT-G subscale and total scores. The SF-6D utility scores and FACT-G subscale scores had a moderate Spearman rank correlation with the corresponding SF-12v2 domain score that conceptually measures the similar construct providing evidence for adequate construct validity. Internal consistency of the FACT-G subscales and total scales were acceptable (α: 0.639-0.850) for all subscales aside from the Emotional well-being subscale (α: 0.581). The HRQOL and utility scores showed excellent test-retest reliability (range: 0.758-0.858). CONCLUSION(s): The SF-6D utility score and cancer-specific FACT-G questionnaire appears to be a valid and reliable measure to assess the HRQOL of Chinese patients diagnosed with incidental thyroid nodules, and thus evaluate the treatment response to those patients. | - |
dc.language | eng | - |
dc.publisher | Sage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=263 | - |
dc.relation.ispartof | Medical Decision Making | - |
dc.rights | Medical Decision Making. Copyright © Sage Science Press (US). | - |
dc.title | Applicability and Psychometric Evaluation of Utility and Cancer-Specific Health-Related Quality of Life Measures in patients with Incidental Thyroid Nodules | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Wong, CKH: carlosho@hku.hk | - |
dc.identifier.email | Lang, HHB: blang@hkucc.hku.hk | - |
dc.identifier.authority | Wong, CKH=rp01931 | - |
dc.identifier.authority | Lang, HHB=rp01828 | - |
dc.identifier.doi | 10.1177/0272989X16665121 | - |
dc.identifier.hkuros | 266419 | - |
dc.identifier.volume | 36 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | E510 | - |
dc.identifier.epage | E511 | - |
dc.identifier.isi | WOS:000383031000002 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0272-989X | - |