Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs

Abstract

The mid-term and long-term impacts of bone grafting materials of different hydroxyapatite (HA) and tricalcium phosphate (TCE) ratios (80/20, 60/40, and 20/80) on bone formation, graft degradation, and osteoconduction in Minipigs was investigated. Three organized intraosseous defects were prepared on each sides of the mandible using a trephine in 24 Minipigs. Coagulum and autograft defects initially showed the fastest and most mature bone formation. 20/80 showed a high resorption rate similar to autograft, whereas 80/20 and 60/40 showed a very low and identical degradation rate. The amount of bone formation looked to be directly related to the concentration of TCP in the BCP. It was observed that the superficial dissolution of TCP in the BCP apatite crystal is helpful for re- precipitation of a biological apatite layer on the surface of the biomaterials, which in turn helps osteoconduction.