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Article: Phototriggered Local Anesthesia

TitlePhototriggered Local Anesthesia
Authors
Zhan, ChangyouWang, WeipingMcAlvin, James B.Guo, ShutaoTimko, Brian P.Santamaria, ClaudiaKohane, Daniel S.
KeywordsPhototriggering
gold nanorod
liposome
local anesthesia
tetrodotoxin
Issue Date2016
Citation
Nano Letters, 2016, v. 16, n. 1, p. 177-181 How to Cite?
DOI: http://dx.doi.org/10.1021/acs.nanolett.5b03440
Abstract© 2015 American Chemical Society.We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain.
Persistent Identifierhttp://hdl.handle.net/10722/236726
ISSN
1530-6984
2023 Impact Factor: 9.6
2023 SCImago Journal Rankings: 3.411
ISI Accession Number ID
WOS:000368322700028

 

DC FieldValueLanguage
dc.contributor.authorZhan, Changyou-
dc.contributor.authorWang, Weiping-
dc.contributor.authorMcAlvin, James B.-
dc.contributor.authorGuo, Shutao-
dc.contributor.authorTimko, Brian P.-
dc.contributor.authorSantamaria, Claudia-
dc.contributor.authorKohane, Daniel S.-
dc.date.accessioned2016-12-02T03:07:29Z-
dc.date.available2016-12-02T03:07:29Z-
dc.date.issued2016-
dc.identifier.citationNano Letters, 2016, v. 16, n. 1, p. 177-181-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/236726-
dc.description.abstract© 2015 American Chemical Society.We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain.-
dc.languageeng-
dc.relation.ispartofNano Letters-
dc.subjectPhototriggering-
dc.subjectgold nanorod-
dc.subjectliposome-
dc.subjectlocal anesthesia-
dc.subjecttetrodotoxin-
dc.titlePhototriggered Local Anesthesia-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.nanolett.5b03440-
dc.identifier.scopuseid_2-s2.0-84957588286-
dc.identifier.volume16-
dc.identifier.issue1-
dc.identifier.spage177-
dc.identifier.epage181-
dc.identifier.eissn1530-6992-
dc.identifier.isiWOS:000368322700028-
dc.identifier.issnl1530-6984-

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