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Article: Enhanced precision of nanoparticle phototargeting in vivo at a safe irradiance

TitleEnhanced precision of nanoparticle phototargeting in vivo at a safe irradiance
Authors
Liu, QianWang, WeipingZhan, ChangyouYang, TiansheKohane, Daniel S.
Keywordsphototargeted nanoparticles
photoresponsive binding
photon upconversion
photocleavage
Caged ligands
Issue Date2016
Citation
Nano Letters, 2016, v. 16, n. 7, p. 4516-4520 How to Cite?
DOI: http://dx.doi.org/10.1021/acs.nanolett.6b01730
Abstract© 2016 American Chemical Society.A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm2) over a short period (5 min) using green light.
Persistent Identifierhttp://hdl.handle.net/10722/236727
ISSN
1530-6984
2023 Impact Factor: 9.6
2023 SCImago Journal Rankings: 3.411
ISI Accession Number ID
WOS:000379794200079

 

DC FieldValueLanguage
dc.contributor.authorLiu, Qian-
dc.contributor.authorWang, Weiping-
dc.contributor.authorZhan, Changyou-
dc.contributor.authorYang, Tianshe-
dc.contributor.authorKohane, Daniel S.-
dc.date.accessioned2016-12-02T03:07:29Z-
dc.date.available2016-12-02T03:07:29Z-
dc.date.issued2016-
dc.identifier.citationNano Letters, 2016, v. 16, n. 7, p. 4516-4520-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/236727-
dc.description.abstract© 2016 American Chemical Society.A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm2) over a short period (5 min) using green light.-
dc.languageeng-
dc.relation.ispartofNano Letters-
dc.subjectphototargeted nanoparticles-
dc.subjectphotoresponsive binding-
dc.subjectphoton upconversion-
dc.subjectphotocleavage-
dc.subjectCaged ligands-
dc.titleEnhanced precision of nanoparticle phototargeting in vivo at a safe irradiance-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.nanolett.6b01730-
dc.identifier.scopuseid_2-s2.0-84978708876-
dc.identifier.volume16-
dc.identifier.issue7-
dc.identifier.spage4516-
dc.identifier.epage4520-
dc.identifier.eissn1530-6992-
dc.identifier.isiWOS:000379794200079-
dc.identifier.issnl1530-6984-

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