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Article: A zwitterionic 1D/2D polymer co-crystal and its polymorphic sub-components: A highly selective sensing platform for HIV ds-DNA sequences

TitleA zwitterionic 1D/2D polymer co-crystal and its polymorphic sub-components: A highly selective sensing platform for HIV ds-DNA sequences
Authors
Issue Date2016
Citation
Dalton Transactions, 2016, v. 45, n. 12, p. 5092-5100 How to Cite?
Abstract© The Royal Society of Chemistry 2016.Polymorphic compounds {[Cu(dcbb)2(H2O)2]·10H2O}n (2, 1D chain), [Cu(dcbb)2]n (3, 2D layer) and their co-crystal {[Cu(dcbb)2(H2O)][Cu(dcbb)2]2}n (4) have been prepared from the coordination reaction of a 2D polymer [Na(dcbb)(H2O)]n (1, H2dcbbBr = 1-(3,5-dicarboxybenzyl)-4,4′-bipyridinium bromide) with Cu(NO3)2·3H2O at different temperatures in water. Compounds 2-4 have an identical metal-to-ligand stoichiometric ratio of 1:2, but absolutely differ in structure. Compound 3 features a 2D layer structure with aromatic rings, positively charged pyridinium and free carboxylates on its surface, promoting electrostatic, π-stacking and/or hydrogen-bonding interactions with the carboxyfluorescein (FAM) labeled probe single-stranded DNA (probe ss-DNA, delineates as P-DNA). The resultant P-DNA@3 system facilitated fluorescence quenching of FAM via a photoinduced electron transfer process. The P-DNA@3 system functions as an efficient fluorescent sensor selective for HIV double-stranded DNA (HIV ds-DNA) due to the formation of a rigid triplex structure with the recovery of FAM fluorescence. The system reported herein also distinguishes complementary HIV ds-DNA from mismatched target DNA sequences with the detection limit of 1.42 nM.
Persistent Identifierhttp://hdl.handle.net/10722/237525
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 0.697
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Hai Qing-
dc.contributor.authorYang, Shui Ping-
dc.contributor.authorDing, Ni Ni-
dc.contributor.authorQin, Liang-
dc.contributor.authorQiu, Gui Hua-
dc.contributor.authorChen, Jin Xiang-
dc.contributor.authorZhang, Wen Hua-
dc.contributor.authorChen, Wen Hua-
dc.contributor.authorHor, T. S Andy-
dc.date.accessioned2017-01-16T06:09:27Z-
dc.date.available2017-01-16T06:09:27Z-
dc.date.issued2016-
dc.identifier.citationDalton Transactions, 2016, v. 45, n. 12, p. 5092-5100-
dc.identifier.issn1477-9226-
dc.identifier.urihttp://hdl.handle.net/10722/237525-
dc.description.abstract© The Royal Society of Chemistry 2016.Polymorphic compounds {[Cu(dcbb)2(H2O)2]·10H2O}n (2, 1D chain), [Cu(dcbb)2]n (3, 2D layer) and their co-crystal {[Cu(dcbb)2(H2O)][Cu(dcbb)2]2}n (4) have been prepared from the coordination reaction of a 2D polymer [Na(dcbb)(H2O)]n (1, H2dcbbBr = 1-(3,5-dicarboxybenzyl)-4,4′-bipyridinium bromide) with Cu(NO3)2·3H2O at different temperatures in water. Compounds 2-4 have an identical metal-to-ligand stoichiometric ratio of 1:2, but absolutely differ in structure. Compound 3 features a 2D layer structure with aromatic rings, positively charged pyridinium and free carboxylates on its surface, promoting electrostatic, π-stacking and/or hydrogen-bonding interactions with the carboxyfluorescein (FAM) labeled probe single-stranded DNA (probe ss-DNA, delineates as P-DNA). The resultant P-DNA@3 system facilitated fluorescence quenching of FAM via a photoinduced electron transfer process. The P-DNA@3 system functions as an efficient fluorescent sensor selective for HIV double-stranded DNA (HIV ds-DNA) due to the formation of a rigid triplex structure with the recovery of FAM fluorescence. The system reported herein also distinguishes complementary HIV ds-DNA from mismatched target DNA sequences with the detection limit of 1.42 nM.-
dc.languageeng-
dc.relation.ispartofDalton Transactions-
dc.titleA zwitterionic 1D/2D polymer co-crystal and its polymorphic sub-components: A highly selective sensing platform for HIV ds-DNA sequences-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c5dt04410c-
dc.identifier.scopuseid_2-s2.0-84962590480-
dc.identifier.hkuros285678-
dc.identifier.volume45-
dc.identifier.issue12-
dc.identifier.spage5092-
dc.identifier.epage5100-
dc.identifier.eissn1477-9234-
dc.identifier.isiWOS:000372187700021-
dc.identifier.issnl1477-9226-

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