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Article: Synthesis, X-ray structures, and cytotoxicity of rhenium(I) carbonyl 2-(dimethylamino)ethoxide complexes

TitleSynthesis, X-ray structures, and cytotoxicity of rhenium(I) carbonyl 2-(dimethylamino)ethoxide complexes
Authors
KeywordsHydrogen-bonding
Cytotoxicity
Carbonyl
Aminoalcohol
Rhenium(I)
Oxidative-alkoxylation
Issue Date2002
Citation
Polyhedron, 2002, v. 21, n. 20, p. 1991-1999 How to Cite?
AbstractThe complexes [Re(η2-Me2NCH2CH2O) (CO)3(μ-OH)Re(η2-Me2 NCH2CH2OH)(CO)3] (1) and [Re3(μ3-OH)(μ-OH)2(μ-OCH2 CH2NMe2H)(CO)9] (2) have been synthesised and characterised by single-crystal X-ray diffraction analysis. Complex 1 exists as hydrogen-bonded dimers in the solid state and in solution. Proton NMR, 1H-1H COSY and NOESY spectroscopic studies showed that the structure of 1 is static in solution, and that only one of the many possible geometric isomers of 1 exists. The hydrogen atom on the ammonio nitrogen of 2 is involved in intramolecular N-H⋯O hydrogen-bonding with a bridging OH group. Complexes 1 and 2 were shown to be potent in suspended tumour cell lines in suppressing growth but were more selective in inhibiting the growth of cultures from solid tumours. The compounds [NBun4][ReO4] and [NEt4]2[ReBr3(CO)3] were also very active against the suspended cell lines and selective against solid tumours. All the compounds tested are inactive against normal cells. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/237554
ISSN
2020 Impact Factor: 3.052
2015 SCImago Journal Rankings: 0.592
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Wenwu-
dc.contributor.authorYan, Yaw Kai-
dc.contributor.authorAndy Hor, T. S.-
dc.contributor.authorVittal, Jagadese J.-
dc.contributor.authorWheaton, Jessica R.-
dc.contributor.authorHall, Iris H.-
dc.date.accessioned2017-01-16T06:09:43Z-
dc.date.available2017-01-16T06:09:43Z-
dc.date.issued2002-
dc.identifier.citationPolyhedron, 2002, v. 21, n. 20, p. 1991-1999-
dc.identifier.issn0277-5387-
dc.identifier.urihttp://hdl.handle.net/10722/237554-
dc.description.abstractThe complexes [Re(η2-Me2NCH2CH2O) (CO)3(μ-OH)Re(η2-Me2 NCH2CH2OH)(CO)3] (1) and [Re3(μ3-OH)(μ-OH)2(μ-OCH2 CH2NMe2H)(CO)9] (2) have been synthesised and characterised by single-crystal X-ray diffraction analysis. Complex 1 exists as hydrogen-bonded dimers in the solid state and in solution. Proton NMR, 1H-1H COSY and NOESY spectroscopic studies showed that the structure of 1 is static in solution, and that only one of the many possible geometric isomers of 1 exists. The hydrogen atom on the ammonio nitrogen of 2 is involved in intramolecular N-H⋯O hydrogen-bonding with a bridging OH group. Complexes 1 and 2 were shown to be potent in suspended tumour cell lines in suppressing growth but were more selective in inhibiting the growth of cultures from solid tumours. The compounds [NBun4][ReO4] and [NEt4]2[ReBr3(CO)3] were also very active against the suspended cell lines and selective against solid tumours. All the compounds tested are inactive against normal cells. © 2002 Elsevier Science Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofPolyhedron-
dc.subjectHydrogen-bonding-
dc.subjectCytotoxicity-
dc.subjectCarbonyl-
dc.subjectAminoalcohol-
dc.subjectRhenium(I)-
dc.subjectOxidative-alkoxylation-
dc.titleSynthesis, X-ray structures, and cytotoxicity of rhenium(I) carbonyl 2-(dimethylamino)ethoxide complexes-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0277-5387(02)01045-8-
dc.identifier.scopuseid_2-s2.0-0036715459-
dc.identifier.volume21-
dc.identifier.issue20-
dc.identifier.spage1991-
dc.identifier.epage1999-
dc.identifier.isiWOS:000178269000004-
dc.identifier.issnl0277-5387-

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