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Article: Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances

TitleIsolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances
Authors
Yeo, JMTse, VKung, JLin, HYLee, YTKwan, JYan, BPTse, G
KeywordsAnimal models
Cardiac electrophysiology
Langendorff mode
Perfusate composition
Perfusion methods
Species differences
Working mode
Issue Date2017
PublisherWalter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/jbcpp
Citation
Journal of Basic and Clinical Physiology and Pharmacology, 2017, v. 28 n. 3, p. 191-200 How to Cite?
DOI: http://dx.doi.org/10.1515/jbcpp-2016-0110
AbstractExperimental models used in cardiovascular research range from cellular to whole heart preparations. Isolated whole hearts show higher levels of structural and functional integration than lower level models such as tissues or cellular fragments. Cardiovascular diseases are multi-factorial problems that are dependent on highly organized structures rather than on molecular or cellular components alone. This article first provides a general introduction on the animal models of cardiovascular diseases. It is followed by a detailed overview and a historical perspective of the different isolated heart systems with a particular focus on the Langendorff perfusion method for the study of cardiac arrhythmias. The choice of species, perfusion method, and perfusate composition are discussed in further detail with particular considerations of the theoretical and practical aspects of experimental settings.
Persistent Identifierhttp://hdl.handle.net/10722/238673
ISSN
0792-6855
2020 SCImago Journal Rankings: 0.414

 

DC FieldValueLanguage
dc.contributor.authorYeo, JM-
dc.contributor.authorTse, V-
dc.contributor.authorKung, J-
dc.contributor.authorLin, HY-
dc.contributor.authorLee, YT-
dc.contributor.authorKwan, J-
dc.contributor.authorYan, BP-
dc.contributor.authorTse, G-
dc.date.accessioned2017-02-20T01:24:36Z-
dc.date.available2017-02-20T01:24:36Z-
dc.date.issued2017-
dc.identifier.citationJournal of Basic and Clinical Physiology and Pharmacology, 2017, v. 28 n. 3, p. 191-200-
dc.identifier.issn0792-6855-
dc.identifier.urihttp://hdl.handle.net/10722/238673-
dc.description.abstractExperimental models used in cardiovascular research range from cellular to whole heart preparations. Isolated whole hearts show higher levels of structural and functional integration than lower level models such as tissues or cellular fragments. Cardiovascular diseases are multi-factorial problems that are dependent on highly organized structures rather than on molecular or cellular components alone. This article first provides a general introduction on the animal models of cardiovascular diseases. It is followed by a detailed overview and a historical perspective of the different isolated heart systems with a particular focus on the Langendorff perfusion method for the study of cardiac arrhythmias. The choice of species, perfusion method, and perfusate composition are discussed in further detail with particular considerations of the theoretical and practical aspects of experimental settings.-
dc.languageeng-
dc.publisherWalter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/jbcpp-
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacology-
dc.rights© 2017 Walter de Gruyter GmbH, Berlin/Boston. The final publication is available at www.degruyter.com-
dc.subjectAnimal models-
dc.subjectCardiac electrophysiology-
dc.subjectLangendorff mode-
dc.subjectPerfusate composition-
dc.subjectPerfusion methods-
dc.subjectSpecies differences-
dc.subjectWorking mode-
dc.titleIsolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances-
dc.typeArticle-
dc.identifier.emailKwan, J: jskkwan@hku.hk-
dc.identifier.authorityKwan, J=rp01868-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1515/jbcpp-2016-0110-
dc.identifier.pmid28063261-
dc.identifier.scopuseid_2-s2.0-85019145115-
dc.identifier.hkuros271386-
dc.identifier.volume28-
dc.identifier.issue3-
dc.identifier.spage191-
dc.identifier.epage200-
dc.publisher.placeGermany-
dc.identifier.issnl0792-6855-

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