File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Reinforcement learning deficits in patients with first-episode schizophrenia-spectrum disorder
Title | Reinforcement learning deficits in patients with first-episode schizophrenia-spectrum disorder |
---|---|
Authors | |
Issue Date | 2016 |
Publisher | The University of Hong Kong. |
Citation | The 2016 Neuroscience Symposium and Annual Scientific Conference of the Hong Kong Society of Neurosciences, The University of Hong Kong, Hong Kong, 18 May 2016. In Programme Book, 2016, p. 17, abstract no. S1 How to Cite? |
Abstract | Numerous studies have identified reinforcement learning (RL) deficits in schizophrenia. Most have focused on chronic patients with longstanding antipsychotic treatment, however, and studies of RL in early-illness patients have produced mixed results, particularly regarding gradual/procedural learning. No study has directly contrasted both rapid and gradual RL in first-episode psychosis (FEP) samples. We examined probabilistic RL in 34 FEP patients and 36 controls, using Go/NoGo (GNG) and Gain vs. Loss-Avoidance (GLA) paradigms. Our results were mixed, with FEP patients exhibiting greater impairment in the ability to use positive, as opposed to negative, feedback to drive rapid RL on the GLA, but not the GNG. By contrast, patients and controls showed similar improvement across the acquisition. Finally, we found no significant between-group differences in the post-acquisition expression of value-based preference in both tasks. Negative symptoms were modestly associated with RL measures, while the overall bias to engage in Go-responding correlated significantly with psychosis severity in FEP patients, consistent with striatal hyperdopaminergia. Taken together, FEP patients demonstrated more circumscribed RL impairments than previous studies have documented in chronic samples, possibly reflecting differential symptom profiles between first-episode and chronic samples. Our finding of relatively
preserved gradual/procedural RL, in briefly-medicated FEP patients, might suggest spared or restored basal ganglia function. Our findings of preserved abilities to use representations of expected value to guide decision-making, and our mixed results regarding rapid RL, may reflect a lesser degree of prefrontal cortical functional impairment in FEP than in chronic samples. Further longitudinal research, in larger samples, is required. |
Description | Invited Speaker - Symposium I: S1 Conference Theme: Nature and Nurture in Brain Functions |
Persistent Identifier | http://hdl.handle.net/10722/239265 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, WC | - |
dc.date.accessioned | 2017-03-13T10:26:04Z | - |
dc.date.available | 2017-03-13T10:26:04Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | The 2016 Neuroscience Symposium and Annual Scientific Conference of the Hong Kong Society of Neurosciences, The University of Hong Kong, Hong Kong, 18 May 2016. In Programme Book, 2016, p. 17, abstract no. S1 | - |
dc.identifier.uri | http://hdl.handle.net/10722/239265 | - |
dc.description | Invited Speaker - Symposium I: S1 | - |
dc.description | Conference Theme: Nature and Nurture in Brain Functions | - |
dc.description.abstract | Numerous studies have identified reinforcement learning (RL) deficits in schizophrenia. Most have focused on chronic patients with longstanding antipsychotic treatment, however, and studies of RL in early-illness patients have produced mixed results, particularly regarding gradual/procedural learning. No study has directly contrasted both rapid and gradual RL in first-episode psychosis (FEP) samples. We examined probabilistic RL in 34 FEP patients and 36 controls, using Go/NoGo (GNG) and Gain vs. Loss-Avoidance (GLA) paradigms. Our results were mixed, with FEP patients exhibiting greater impairment in the ability to use positive, as opposed to negative, feedback to drive rapid RL on the GLA, but not the GNG. By contrast, patients and controls showed similar improvement across the acquisition. Finally, we found no significant between-group differences in the post-acquisition expression of value-based preference in both tasks. Negative symptoms were modestly associated with RL measures, while the overall bias to engage in Go-responding correlated significantly with psychosis severity in FEP patients, consistent with striatal hyperdopaminergia. Taken together, FEP patients demonstrated more circumscribed RL impairments than previous studies have documented in chronic samples, possibly reflecting differential symptom profiles between first-episode and chronic samples. Our finding of relatively preserved gradual/procedural RL, in briefly-medicated FEP patients, might suggest spared or restored basal ganglia function. Our findings of preserved abilities to use representations of expected value to guide decision-making, and our mixed results regarding rapid RL, may reflect a lesser degree of prefrontal cortical functional impairment in FEP than in chronic samples. Further longitudinal research, in larger samples, is required. | - |
dc.language | eng | - |
dc.publisher | The University of Hong Kong. | - |
dc.relation.ispartof | Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences | - |
dc.title | Reinforcement learning deficits in patients with first-episode schizophrenia-spectrum disorder | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chang, WC: changwc@hku.hk | - |
dc.identifier.authority | Chang, WC=rp01465 | - |
dc.identifier.hkuros | 266114 | - |
dc.identifier.spage | 17 | - |
dc.identifier.epage | 17 | - |
dc.publisher.place | Hong Kong | - |