File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association between high expression of phosphorylated Akt and mammalian target of rapamycin and improved survival in salivary gland adenoid cystic carcinoma

TitleAssociation between high expression of phosphorylated Akt and mammalian target of rapamycin and improved survival in salivary gland adenoid cystic carcinoma
Authors
KeywordsPhosphotidylinositol‐3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
Adenoid cystic carcinoma
Prognostic biomarker
Salivary gland cancer
Insulin‐like growth factor‐1 receptor (IGF‐1R)
Issue Date2017
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347
Citation
Head & Neck, 2017, v. 39 n. 6, p. 1145-1154 How to Cite?
AbstractBackground: Previous genomic studies revealed phosphotidylinositol‐3‐kinase (PI3K)/Akt pathway mutation in human salivary gland adenoid cystic carcinoma (ACC). No validation of its prognostic value has been reported. Methods: P‐Akt, pan‐Akt, phosphorylated‐mammalian target of rapamycin (p‐mTOR), PI3K, and insulin‐like growth factor‐1 receptor beta (IGF‐1Rβ) were detected on 120 salivary gland ACC/adjacent salivary gland pairs immunohistochemically and were correlated with clinicopathological data. Results: Expression of cytoplasmic and nuclear p‐Akt, cytoplasmic p‐mTOR, nuclear pan‐Akt, and nuclear IGF‐1Rβ were higher in ACC than in adjacent salivary glands. P‐Akt, p‐mTOR, PI3K, and IGF‐1Rβ expression were correlated with one another in both cytoplasm and nucleus. Low p‐mTOR expression in both subcellular compartments was associated with locoregional recurrence, poor disease‐free survival (DFS), and overall survival (OS). Low nuclear p‐Akt (Ser473) and p‐mTOR expression were independent predictors for poor OS and DFS, respectively. Conclusion: High level of Akt/mTOR activation in ACC is correlated with a significantly improved survival. P‐mTOR and nuclear p‐Akt are prognostic biomarkers of salivary gland ACC. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1145–1154, 2017
Persistent Identifierhttp://hdl.handle.net/10722/240898
ISSN
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 1.034
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorQuyang, DQ-
dc.contributor.authorLiang, LZ-
dc.contributor.authorKe, ZF-
dc.contributor.authorZheng, GS-
dc.contributor.authorWeng, DS-
dc.contributor.authorYang, WF-
dc.contributor.authorSu, YX-
dc.contributor.authorLiao, GQ-
dc.date.accessioned2017-05-22T09:19:05Z-
dc.date.available2017-05-22T09:19:05Z-
dc.date.issued2017-
dc.identifier.citationHead & Neck, 2017, v. 39 n. 6, p. 1145-1154-
dc.identifier.issn1043-3074-
dc.identifier.urihttp://hdl.handle.net/10722/240898-
dc.description.abstractBackground: Previous genomic studies revealed phosphotidylinositol‐3‐kinase (PI3K)/Akt pathway mutation in human salivary gland adenoid cystic carcinoma (ACC). No validation of its prognostic value has been reported. Methods: P‐Akt, pan‐Akt, phosphorylated‐mammalian target of rapamycin (p‐mTOR), PI3K, and insulin‐like growth factor‐1 receptor beta (IGF‐1Rβ) were detected on 120 salivary gland ACC/adjacent salivary gland pairs immunohistochemically and were correlated with clinicopathological data. Results: Expression of cytoplasmic and nuclear p‐Akt, cytoplasmic p‐mTOR, nuclear pan‐Akt, and nuclear IGF‐1Rβ were higher in ACC than in adjacent salivary glands. P‐Akt, p‐mTOR, PI3K, and IGF‐1Rβ expression were correlated with one another in both cytoplasm and nucleus. Low p‐mTOR expression in both subcellular compartments was associated with locoregional recurrence, poor disease‐free survival (DFS), and overall survival (OS). Low nuclear p‐Akt (Ser473) and p‐mTOR expression were independent predictors for poor OS and DFS, respectively. Conclusion: High level of Akt/mTOR activation in ACC is correlated with a significantly improved survival. P‐mTOR and nuclear p‐Akt are prognostic biomarkers of salivary gland ACC. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1145–1154, 2017-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347-
dc.relation.ispartofHead & Neck-
dc.subjectPhosphotidylinositol‐3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)-
dc.subjectAdenoid cystic carcinoma-
dc.subjectPrognostic biomarker-
dc.subjectSalivary gland cancer-
dc.subjectInsulin‐like growth factor‐1 receptor (IGF‐1R)-
dc.titleAssociation between high expression of phosphorylated Akt and mammalian target of rapamycin and improved survival in salivary gland adenoid cystic carcinoma-
dc.typeArticle-
dc.identifier.emailSu, YX: richsu@hku.hk-
dc.identifier.authoritySu, YX=rp01916-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.24732-
dc.identifier.pmid28230926-
dc.identifier.scopuseid_2-s2.0-85013631829-
dc.identifier.hkuros272253-
dc.identifier.volume39-
dc.identifier.issue6-
dc.identifier.spage1145-
dc.identifier.epage1154-
dc.identifier.isiWOS:000401269000013-
dc.publisher.placeUnited States-
dc.identifier.issnl1043-3074-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats