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Article: Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study

TitleRisk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study
Authors
KeywordsAdenoid cystic carcinoma
Lymphovascular invasion
Postoperative radiotherapy
Salivary gland
Issue Date2017
PublisherLippincott, Williams & Wilkins: Various Creative Commons. The Journal's web site is located at http://journals.lww.com/md-journal/pages/default.aspx
Citation
Medicine, 2017, v. 96 n. 5, article no. e5964, p. 1-6 How to Cite?
AbstractAdenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and high incidence of distant metastasis (DM). The aim of this study was to evaluate predictive factors for local-regional (LR) recurrence, DM, and survival in ACC. A retrospective review of the medical records for patients with salivary glands ACC from 1990 to 2015 was performed. The clinical parameters were assessed to identify correlations with the development of LR recurrence, DM, and survival of these patients. Among 228 patients who underwent surgery as definitive treatment, 210 (92.1%) were followed up in the study. DM was detected in 64 (30.5%) patients, LR recurrence was detected in 58 (27.6%) patients. The estimated 5, 10, and 15-year overall survival rates were 84.7%, 70.8%, and 34.0%, respectively. Multivariate analysis revealed that the presence of lymphovascular invasion and a high T classification were very strong adverse factors, which independently influenced LR recurrence, DM, and survival of ACC patients. Positive/close margin and N+ status were independent risk factors for DM and LR recurrence, respectively. Survival of ACC patents was also affected by tumor location. Presence of lymphovascular invasion and a high T classification were very strong adverse factors and independent predictors for ACC patients’ prognosis, which influenced LR control, DM control, and survival.
Persistent Identifierhttp://hdl.handle.net/10722/240899
ISSN
2020 Impact Factor: 1.889
2020 SCImago Journal Rankings: 0.590
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOuyang, DQ-
dc.contributor.authorLiang, LZ-
dc.contributor.authorZheng, GS-
dc.contributor.authorKe, ZF-
dc.contributor.authorWeng, DS-
dc.contributor.authorYang, WF-
dc.contributor.authorSu, YX-
dc.contributor.authorLiao, GQ-
dc.date.accessioned2017-05-22T09:19:06Z-
dc.date.available2017-05-22T09:19:06Z-
dc.date.issued2017-
dc.identifier.citationMedicine, 2017, v. 96 n. 5, article no. e5964, p. 1-6-
dc.identifier.issn0025-7974-
dc.identifier.urihttp://hdl.handle.net/10722/240899-
dc.description.abstractAdenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and high incidence of distant metastasis (DM). The aim of this study was to evaluate predictive factors for local-regional (LR) recurrence, DM, and survival in ACC. A retrospective review of the medical records for patients with salivary glands ACC from 1990 to 2015 was performed. The clinical parameters were assessed to identify correlations with the development of LR recurrence, DM, and survival of these patients. Among 228 patients who underwent surgery as definitive treatment, 210 (92.1%) were followed up in the study. DM was detected in 64 (30.5%) patients, LR recurrence was detected in 58 (27.6%) patients. The estimated 5, 10, and 15-year overall survival rates were 84.7%, 70.8%, and 34.0%, respectively. Multivariate analysis revealed that the presence of lymphovascular invasion and a high T classification were very strong adverse factors, which independently influenced LR recurrence, DM, and survival of ACC patients. Positive/close margin and N+ status were independent risk factors for DM and LR recurrence, respectively. Survival of ACC patents was also affected by tumor location. Presence of lymphovascular invasion and a high T classification were very strong adverse factors and independent predictors for ACC patients’ prognosis, which influenced LR control, DM control, and survival.-
dc.languageeng-
dc.publisherLippincott, Williams & Wilkins: Various Creative Commons. The Journal's web site is located at http://journals.lww.com/md-journal/pages/default.aspx-
dc.relation.ispartofMedicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdenoid cystic carcinoma-
dc.subjectLymphovascular invasion-
dc.subjectPostoperative radiotherapy-
dc.subjectSalivary gland-
dc.titleRisk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study-
dc.typeArticle-
dc.identifier.emailSu, Y: richsu@hku.hk-
dc.identifier.authoritySu, Y=rp01916-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1097/MD.0000000000005964-
dc.identifier.pmid28151884-
dc.identifier.pmcidPMC5293447-
dc.identifier.scopuseid_2-s2.0-85013173983-
dc.identifier.hkuros272254-
dc.identifier.volume96-
dc.identifier.issue5-
dc.identifier.spagearticle no. e5964, p. 1-
dc.identifier.epagearticle no. e5964, p. 6-
dc.identifier.isiWOS:000394253800037-
dc.publisher.placeUnited States-
dc.identifier.issnl0025-7974-

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