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- Publisher Website: 10.3174/ajnr.A5226
- Scopus: eid_2-s2.0-85020549724
- PMID: 28450434
- WOS: WOS:000402627400029
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Article: Characterization of Extensive Microstructural Variations Associated with Punctate White Matter Lesions in Preterm Neonates
Title | Characterization of Extensive Microstructural Variations Associated with Punctate White Matter Lesions in Preterm Neonates |
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Authors | |
Issue Date | 2017 |
Publisher | American Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org |
Citation | American Journal of Neuroradiology, 2017, v. 38 n. 6, p. 1228-1234 How to Cite? |
Abstract | BACKGROUND AND PURPOSE: Punctate white matter lesions are common in preterm neonates. Neurodevelopmental outcomes of the neonates are related to the degree of extension. This study aimed to characterize the extent of microstructural variations for different punctate white matter lesion grades. MATERIALS AND METHODS: Preterm neonates with punctate white matter lesions were divided into 3 grades (from mild to severe: grades I-III). DTI-derived fractional anisotropy, axial diffusivity, and radial diffusivity between patients with punctate white matter lesions and controls were compared with Tract-Based Spatial Statistics and tract-quantification methods. RESULTS: Thirty-three preterm neonates with punctate white matter lesions and 33 matched controls were enrolled. There were 15, 9, and 9 patients, respectively, in grades I, II, and III. Punctate white matter lesions were mainly located in white matter adjacent to the lateral ventricles, especially regions lateral to the trigone, posterior horns, and centrum semiovale and/or corona radiata. Extensive microstructural changes were observed in neonates with grade III punctate white matter lesions, while no significant changes in DTI metrics were found for grades I and II. A pattern of increased axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy was found in regions adjacent to punctate white matter lesion sites seen on T1WI and T2WI. Unchanged axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy were observed in regions distant from punctate white matter lesion sites. CONCLUSIONS: White matter microstructural variations were different across punctate white matter lesion grades. Extensive change patterns varied according to the distance to the lesion sites in neonates with severe punctate white matter lesions. These findings may help in determining the outcomes of punctate white matter lesions and selecting treatment strategies. © 2017, American Society of Neuroradiology. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/240915 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.020 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, X | - |
dc.contributor.author | Gao, J | - |
dc.contributor.author | Wang, M | - |
dc.contributor.author | Zheng, J | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Hui, SK | - |
dc.contributor.author | Wan, M | - |
dc.contributor.author | Yang, JH | - |
dc.date.accessioned | 2017-05-22T09:19:24Z | - |
dc.date.available | 2017-05-22T09:19:24Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | American Journal of Neuroradiology, 2017, v. 38 n. 6, p. 1228-1234 | - |
dc.identifier.issn | 0195-6108 | - |
dc.identifier.uri | http://hdl.handle.net/10722/240915 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: Punctate white matter lesions are common in preterm neonates. Neurodevelopmental outcomes of the neonates are related to the degree of extension. This study aimed to characterize the extent of microstructural variations for different punctate white matter lesion grades. MATERIALS AND METHODS: Preterm neonates with punctate white matter lesions were divided into 3 grades (from mild to severe: grades I-III). DTI-derived fractional anisotropy, axial diffusivity, and radial diffusivity between patients with punctate white matter lesions and controls were compared with Tract-Based Spatial Statistics and tract-quantification methods. RESULTS: Thirty-three preterm neonates with punctate white matter lesions and 33 matched controls were enrolled. There were 15, 9, and 9 patients, respectively, in grades I, II, and III. Punctate white matter lesions were mainly located in white matter adjacent to the lateral ventricles, especially regions lateral to the trigone, posterior horns, and centrum semiovale and/or corona radiata. Extensive microstructural changes were observed in neonates with grade III punctate white matter lesions, while no significant changes in DTI metrics were found for grades I and II. A pattern of increased axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy was found in regions adjacent to punctate white matter lesion sites seen on T1WI and T2WI. Unchanged axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy were observed in regions distant from punctate white matter lesion sites. CONCLUSIONS: White matter microstructural variations were different across punctate white matter lesion grades. Extensive change patterns varied according to the distance to the lesion sites in neonates with severe punctate white matter lesions. These findings may help in determining the outcomes of punctate white matter lesions and selecting treatment strategies. © 2017, American Society of Neuroradiology. All rights reserved. | - |
dc.language | eng | - |
dc.publisher | American Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org | - |
dc.relation.ispartof | American Journal of Neuroradiology | - |
dc.title | Characterization of Extensive Microstructural Variations Associated with Punctate White Matter Lesions in Preterm Neonates | - |
dc.type | Article | - |
dc.identifier.email | Hui, SK: edshui@hku.hk | - |
dc.identifier.authority | Hui, SK=rp01832 | - |
dc.identifier.doi | 10.3174/ajnr.A5226 | - |
dc.identifier.pmid | 28450434 | - |
dc.identifier.scopus | eid_2-s2.0-85020549724 | - |
dc.identifier.hkuros | 272184 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1228 | - |
dc.identifier.epage | 1234 | - |
dc.identifier.isi | WOS:000402627400029 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0195-6108 | - |