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Article: Recent advances on the encoding and selection methods of DNA-encoded chemical library

TitleRecent advances on the encoding and selection methods of DNA-encoded chemical library
Authors
Shi, BZhou, YHUANG, YZHANG, JLi, X
KeywordsCombinatorial chemistry
DNA-encoded library
Drug discovery
Dynamic combinatorial library
High throughput screening
Issue Date2016
Citation
Bioorg. Med. Chem. Lett. , 2016, v. 27, p. 361-369 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bmcl.2016.12.025
AbstractDNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research.
Persistent Identifierhttp://hdl.handle.net/10722/243009
ISI Accession Number ID
WOS:000392900600001

 

DC FieldValueLanguage
dc.contributor.authorShi, B-
dc.contributor.authorZhou, Y-
dc.contributor.authorHUANG, Y-
dc.contributor.authorZHANG, J-
dc.contributor.authorLi, X-
dc.date.accessioned2017-08-25T02:48:40Z-
dc.date.available2017-08-25T02:48:40Z-
dc.date.issued2016-
dc.identifier.citationBioorg. Med. Chem. Lett. , 2016, v. 27, p. 361-369-
dc.identifier.urihttp://hdl.handle.net/10722/243009-
dc.description.abstractDNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research.-
dc.languageeng-
dc.relation.ispartofBioorg. Med. Chem. Lett. -
dc.subjectCombinatorial chemistry-
dc.subjectDNA-encoded library-
dc.subjectDrug discovery-
dc.subjectDynamic combinatorial library-
dc.subjectHigh throughput screening-
dc.titleRecent advances on the encoding and selection methods of DNA-encoded chemical library-
dc.typeArticle-
dc.identifier.emailShi, B: shibbing@hku.hk-
dc.identifier.emailZhou, Y: yuchow@hku.hk-
dc.identifier.emailLi, X: xiaoyuli@hku.hk-
dc.identifier.authorityLi, X=rp02080-
dc.identifier.doi10.1016/j.bmcl.2016.12.025-
dc.identifier.scopuseid_2-s2.0-85008155944-
dc.identifier.hkuros274754-
dc.identifier.volume27-
dc.identifier.spage361-
dc.identifier.epage369-
dc.identifier.isiWOS:000392900600001-

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