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- Publisher Website: 10.1038/srep10973
- Scopus: eid_2-s2.0-84937938535
- PMID: 26205693
- WOS: WOS:000358418500001
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Article: Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia
Title | Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia |
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Authors | |
Issue Date | 2015 |
Citation | Scientific Reports, 2015, v. 5 How to Cite? |
Abstract | Co-expression analysis reveals useful dysregulation patterns of gene cooperativeness for understanding cancer biology and identifying new targets for treatment. We developed a structural strategy to identify co-expressed gene networks that are important for chronic myelogenous leukemia (CML). This strategy compared the distributions of expressional correlations between CML and normal states, and it identified a data-driven threshold to classify strongly co-expressed networks that had the best coherence with CML. Using this strategy, we found a transcriptome-wide reduction of co-expression connectivity in CML, reflecting potentially loosened molecular regulation. Conversely, when we focused on nucleophosmin 1 (NPM1) associated networks, NPM1 established more co-expression linkages with BCR-ABL pathways and ribosomal protein networks in CML than normal. This finding implicates a new role of NPM1 in conveying tumorigenic signals from the BCR-ABL oncoprotein to ribosome biogenesis, affecting cellular growth. Transcription factors may be regulators of the differential co-expression patterns between CML and normal. |
Persistent Identifier | http://hdl.handle.net/10722/244054 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, Lawrence W.C. | - |
dc.contributor.author | Lin, Xihong | - |
dc.contributor.author | Yung, Godwin | - |
dc.contributor.author | Lui, Thomas | - |
dc.contributor.author | Chiu, Ya Ming | - |
dc.contributor.author | Wang, Fengfeng | - |
dc.contributor.author | Tsui, Nancy B.Y. | - |
dc.contributor.author | Cho, William C.S. | - |
dc.contributor.author | Yip, S. P. | - |
dc.contributor.author | Siu, Parco M. | - |
dc.contributor.author | Wong, S. C.Cesar | - |
dc.contributor.author | Yung, Benjamin Y.M. | - |
dc.date.accessioned | 2017-08-31T08:55:55Z | - |
dc.date.available | 2017-08-31T08:55:55Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Scientific Reports, 2015, v. 5 | - |
dc.identifier.uri | http://hdl.handle.net/10722/244054 | - |
dc.description.abstract | Co-expression analysis reveals useful dysregulation patterns of gene cooperativeness for understanding cancer biology and identifying new targets for treatment. We developed a structural strategy to identify co-expressed gene networks that are important for chronic myelogenous leukemia (CML). This strategy compared the distributions of expressional correlations between CML and normal states, and it identified a data-driven threshold to classify strongly co-expressed networks that had the best coherence with CML. Using this strategy, we found a transcriptome-wide reduction of co-expression connectivity in CML, reflecting potentially loosened molecular regulation. Conversely, when we focused on nucleophosmin 1 (NPM1) associated networks, NPM1 established more co-expression linkages with BCR-ABL pathways and ribosomal protein networks in CML than normal. This finding implicates a new role of NPM1 in conveying tumorigenic signals from the BCR-ABL oncoprotein to ribosome biogenesis, affecting cellular growth. Transcription factors may be regulators of the differential co-expression patterns between CML and normal. | - |
dc.language | eng | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/srep10973 | - |
dc.identifier.pmid | 26205693 | - |
dc.identifier.scopus | eid_2-s2.0-84937938535 | - |
dc.identifier.volume | 5 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.isi | WOS:000358418500001 | - |
dc.identifier.issnl | 2045-2322 | - |