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Article: Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)

TitleMuscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)
Authors
KeywordsMuscle fiber typing
Sarcopenia
Contractile properties
Senescence-accelerated mouse P8 (SAMP8)
Issue Date2015
Citation
Experimental Animals, 2015, v. 64, n. 4, p. 425-433 How to Cite?
Abstract©2015 Japanese Association for Laboratory Animal Science. Sarcopenia is an age-related systemic syndrome with progressive deterioration in skeletal muscle functions and loss in mass. Although the senescence-accelerated mouse P8 (SAMP8) was reported valid for muscular ageing research, there was no report on the details such as sarcopenia onset time. Therefore, this study was to investigate the change of muscle mass, structure and functions during the development of sarcopenia. Besides the average life span, muscle mass, structural and functional measurements were also studied. Male SAMP8 animals were examined at month 6, 7, 8, 9, and 10, in which the right gastrocnemius was isolated and tested for ex vivo contractile properties and fatigability while the contralateral one was harvested for muscle fiber cross-sectional area (FCSA) and typing assessments. Results showed that the peak of muscle mass appeared at month 7 and the onset of contractility decline was observed from month 8. Compared with month 8, mo st of the functional parameters at month 10 decreased significantly. Structurally, muscle fiber type IIA made up the largest proportion of the gastrocnemius, and the fiber size was found to peak at month8. Based on the altered muscle mass, structural and functional outcomes, it was concluded that the onset of sarcopenia in SAMP8 animals was at month 8. SAMP8 animals at month 8 should be at pre-sarcopenia stage while month 10 at sarcopenia stage. It is confirmed that SAMP8 mouse can be used in sarcopenia research with established time line in this study.
Persistent Identifierhttp://hdl.handle.net/10722/244207
ISSN
2023 Impact Factor: 2.2
2023 SCImago Journal Rankings: 0.481

 

DC FieldValueLanguage
dc.contributor.authorGuo, An Yun-
dc.contributor.authorLeung, Kwok Sui-
dc.contributor.authorSiu, Parco Ming Fai-
dc.contributor.authorQin, Jiang Hui-
dc.contributor.authorChow, Simon Kwoon Ho-
dc.contributor.authorQin, Ling-
dc.contributor.authorLi, Chi Yu-
dc.contributor.authorCheung, Wing Hoi-
dc.date.accessioned2017-08-31T08:56:20Z-
dc.date.available2017-08-31T08:56:20Z-
dc.date.issued2015-
dc.identifier.citationExperimental Animals, 2015, v. 64, n. 4, p. 425-433-
dc.identifier.issn1341-1357-
dc.identifier.urihttp://hdl.handle.net/10722/244207-
dc.description.abstract©2015 Japanese Association for Laboratory Animal Science. Sarcopenia is an age-related systemic syndrome with progressive deterioration in skeletal muscle functions and loss in mass. Although the senescence-accelerated mouse P8 (SAMP8) was reported valid for muscular ageing research, there was no report on the details such as sarcopenia onset time. Therefore, this study was to investigate the change of muscle mass, structure and functions during the development of sarcopenia. Besides the average life span, muscle mass, structural and functional measurements were also studied. Male SAMP8 animals were examined at month 6, 7, 8, 9, and 10, in which the right gastrocnemius was isolated and tested for ex vivo contractile properties and fatigability while the contralateral one was harvested for muscle fiber cross-sectional area (FCSA) and typing assessments. Results showed that the peak of muscle mass appeared at month 7 and the onset of contractility decline was observed from month 8. Compared with month 8, mo st of the functional parameters at month 10 decreased significantly. Structurally, muscle fiber type IIA made up the largest proportion of the gastrocnemius, and the fiber size was found to peak at month8. Based on the altered muscle mass, structural and functional outcomes, it was concluded that the onset of sarcopenia in SAMP8 animals was at month 8. SAMP8 animals at month 8 should be at pre-sarcopenia stage while month 10 at sarcopenia stage. It is confirmed that SAMP8 mouse can be used in sarcopenia research with established time line in this study.-
dc.languageeng-
dc.relation.ispartofExperimental Animals-
dc.subjectMuscle fiber typing-
dc.subjectSarcopenia-
dc.subjectContractile properties-
dc.subjectSenescence-accelerated mouse P8 (SAMP8)-
dc.titleMuscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1538/expanim.15-0025-
dc.identifier.pmid26193895-
dc.identifier.scopuseid_2-s2.0-84944716339-
dc.identifier.volume64-
dc.identifier.issue4-
dc.identifier.spage425-
dc.identifier.epage433-
dc.identifier.issnl0007-5124-

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