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Article: Fishing the targets of myeloid malignancies in the era of next generation sequencing

TitleFishing the targets of myeloid malignancies in the era of next generation sequencing
Authors
KeywordsCRISPR/Cas9
Gene mutations
Next generation sequencing
TALEN
Zebrafish
Issue Date2016
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/issn/0268960X
Citation
Blood Reviews, 2016, v. 30 n. 2, p. 119-130 How to Cite?
AbstractRecent advent in next generation sequencing (NGS) and bioinformatics has generated an unprecedented amount of genetic information in myeloidmalignancies. This information may shed lights to the pathogenesis, diagnosis and prognostication of these diseases and provide potential targets for therapeutic intervention. However, the rapid emergence of genetic information will quickly outpace their functional validation by conventional laboratory platforms. Foundational knowledge about zebrafish hematopoiesis accumulated over the past two decades and novel genomeediting technologies and research strategies in thismodel organismhavemade it a unique and timely research tool for the study of human blood diseases. Recent studies modeling human myeloid malignancies in zebrafish have also highlighted the technical feasibility and clinical relevance of thesemodels. Careful validation of experimental protocols and standardization among laboratorieswill further enhance the application of zebrafish in the scientific communities and provide important insights to the personalized treatment ofmyeloid malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/245106
ISSN
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 2.216
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShi, X-
dc.contributor.authorHe, BA-
dc.contributor.authorMa, AC-
dc.contributor.authorLeung, AYH-
dc.date.accessioned2017-09-18T02:04:43Z-
dc.date.available2017-09-18T02:04:43Z-
dc.date.issued2016-
dc.identifier.citationBlood Reviews, 2016, v. 30 n. 2, p. 119-130-
dc.identifier.issn0268-960X-
dc.identifier.urihttp://hdl.handle.net/10722/245106-
dc.description.abstractRecent advent in next generation sequencing (NGS) and bioinformatics has generated an unprecedented amount of genetic information in myeloidmalignancies. This information may shed lights to the pathogenesis, diagnosis and prognostication of these diseases and provide potential targets for therapeutic intervention. However, the rapid emergence of genetic information will quickly outpace their functional validation by conventional laboratory platforms. Foundational knowledge about zebrafish hematopoiesis accumulated over the past two decades and novel genomeediting technologies and research strategies in thismodel organismhavemade it a unique and timely research tool for the study of human blood diseases. Recent studies modeling human myeloid malignancies in zebrafish have also highlighted the technical feasibility and clinical relevance of thesemodels. Careful validation of experimental protocols and standardization among laboratorieswill further enhance the application of zebrafish in the scientific communities and provide important insights to the personalized treatment ofmyeloid malignancies.-
dc.languageeng-
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/issn/0268960X-
dc.relation.ispartofBlood Reviews-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectCRISPR/Cas9-
dc.subjectGene mutations-
dc.subjectNext generation sequencing-
dc.subjectTALEN-
dc.subjectZebrafish-
dc.titleFishing the targets of myeloid malignancies in the era of next generation sequencing-
dc.typeArticle-
dc.identifier.emailHe, BA: alexhe@hku.hk-
dc.identifier.emailLeung, AYH: ayhleung@hku.hk-
dc.identifier.authorityLeung, AYH=rp00265-
dc.identifier.doi10.1016/j.blre.2015.09.001-
dc.identifier.scopuseid_2-s2.0-84946224531-
dc.identifier.hkuros275922-
dc.identifier.volume30-
dc.identifier.issue2-
dc.identifier.spage119-
dc.identifier.epage130-
dc.identifier.isiWOS:000375162000005-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0268-960X-

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