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- Publisher Website: 10.1016/j.tvjl.2016.12.020
- Scopus: eid_2-s2.0-85011995480
- PMID: 28190501
- WOS: WOS:000395218400015
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Article: Middle East respiratory syndrome (MERS) coronavirus and dromedaries
Title | Middle East respiratory syndrome (MERS) coronavirus and dromedaries |
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Authors | |
Keywords | Coronavirus Diagnosis Dromedary Middle East respiratory syndrome (MERS) |
Issue Date | 2017 |
Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/tvjl |
Citation | The Veterinary Journal, 2017, v. 220, p. 75-79 How to Cite? |
Abstract | Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease that can be transmitted from dromedaries to human beings. More than 1500 cases of MERS have been reported in human beings to date. Although MERS has been associated with 30% case fatality in human beings, MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic. In rare cases, dromedaries may develop mild respiratory signs. No MERS-CoV or antibodies against the virus have been detected in camelids other than dromedaries. MERS-CoV is mainly acquired in dromedaries when they are less than 1 year of age, and the proportion of seropositivity increases with age to a seroprevalence of 100% in adult dromedaries. Laboratory diagnosis of MERS-CoV infection in dromedaries can be achieved through virus isolation using Vero cells, RNA detection by real-time quantitative reverse transcriptase-PCR and antigen detection using respiratory specimens or serum. Rapid nucleocapsid antigen detection using a lateral flow platform allows efficient screening of dromedaries carrying MERS-CoV. In addition to MERS-CoV, which is a lineage C virus in the Betacoronavirus (betaCoV) genus, a lineage B betaCoV and a virus in the Alphacoronavirus (alphaCoV) genus have been detected in dromedaries. Dromedary CoV UAE-HKU23 is closely related to human CoV OC43, whereas the alphaCoV has not been detected in human beings to date. |
Persistent Identifier | http://hdl.handle.net/10722/245143 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.739 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wernery, U | - |
dc.contributor.author | Lau, SKP | - |
dc.contributor.author | Woo, PCY | - |
dc.date.accessioned | 2017-09-18T02:05:24Z | - |
dc.date.available | 2017-09-18T02:05:24Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | The Veterinary Journal, 2017, v. 220, p. 75-79 | - |
dc.identifier.issn | 1090-0233 | - |
dc.identifier.uri | http://hdl.handle.net/10722/245143 | - |
dc.description.abstract | Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease that can be transmitted from dromedaries to human beings. More than 1500 cases of MERS have been reported in human beings to date. Although MERS has been associated with 30% case fatality in human beings, MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic. In rare cases, dromedaries may develop mild respiratory signs. No MERS-CoV or antibodies against the virus have been detected in camelids other than dromedaries. MERS-CoV is mainly acquired in dromedaries when they are less than 1 year of age, and the proportion of seropositivity increases with age to a seroprevalence of 100% in adult dromedaries. Laboratory diagnosis of MERS-CoV infection in dromedaries can be achieved through virus isolation using Vero cells, RNA detection by real-time quantitative reverse transcriptase-PCR and antigen detection using respiratory specimens or serum. Rapid nucleocapsid antigen detection using a lateral flow platform allows efficient screening of dromedaries carrying MERS-CoV. In addition to MERS-CoV, which is a lineage C virus in the Betacoronavirus (betaCoV) genus, a lineage B betaCoV and a virus in the Alphacoronavirus (alphaCoV) genus have been detected in dromedaries. Dromedary CoV UAE-HKU23 is closely related to human CoV OC43, whereas the alphaCoV has not been detected in human beings to date. | - |
dc.language | eng | - |
dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/tvjl | - |
dc.relation.ispartof | The Veterinary Journal | - |
dc.rights | Posting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Coronavirus | - |
dc.subject | Diagnosis | - |
dc.subject | Dromedary | - |
dc.subject | Middle East respiratory syndrome (MERS) | - |
dc.title | Middle East respiratory syndrome (MERS) coronavirus and dromedaries | - |
dc.type | Article | - |
dc.identifier.email | Lau, SKP: skplau@hkucc.hku.hk | - |
dc.identifier.email | Woo, PCY: pcywoo@hkucc.hku.hk | - |
dc.identifier.authority | Lau, SKP=rp00486 | - |
dc.identifier.authority | Woo, PCY=rp00430 | - |
dc.identifier.doi | 10.1016/j.tvjl.2016.12.020 | - |
dc.identifier.pmid | 28190501 | - |
dc.identifier.scopus | eid_2-s2.0-85011995480 | - |
dc.identifier.hkuros | 275893 | - |
dc.identifier.volume | 220 | - |
dc.identifier.spage | 75 | - |
dc.identifier.epage | 79 | - |
dc.identifier.isi | WOS:000395218400015 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1090-0233 | - |