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Article: Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus

TitleDysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus
Authors
KeywordsPregnancy
Pandemic influenza A virus
Immune response
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/
Citation
Journal of Infectious Diseases, 2017, v. 217 n. 3, p. 438-442 How to Cite?
AbstractPregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected pregnant and non-pregnant ferrets with A(H1N1) pdm09 virus. A(H1N1)pdm09-infected pregnant ferrets also had higher levels of inflammatory cytokines in their pulmonary tracts. Systemically, total CD8+ T cell counts and A(H1N1)pdm09-specific B-cell responses in blood were significantly lower in pregnant ferrets. This model predicts that the poorer outcome for pregnant women during the A(H1N1)pdm09 pandemic was due to an elevated level of viral replication and to a cytokine imbalance that led to a less effective immune response.
Persistent Identifierhttp://hdl.handle.net/10722/248199
ISSN
2020 Impact Factor: 5.226
2020 SCImago Journal Rankings: 2.690
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYoon, SW-
dc.contributor.authorWong, SS-
dc.contributor.authorZhu, H-
dc.contributor.authorChen, R-
dc.contributor.authorLi, L-
dc.contributor.authorZhang, Y-
dc.contributor.authorGuan, Y-
dc.contributor.authorWebby, RJ-
dc.date.accessioned2017-10-18T08:39:26Z-
dc.date.available2017-10-18T08:39:26Z-
dc.date.issued2017-
dc.identifier.citationJournal of Infectious Diseases, 2017, v. 217 n. 3, p. 438-442-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/248199-
dc.description.abstractPregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected pregnant and non-pregnant ferrets with A(H1N1) pdm09 virus. A(H1N1)pdm09-infected pregnant ferrets also had higher levels of inflammatory cytokines in their pulmonary tracts. Systemically, total CD8+ T cell counts and A(H1N1)pdm09-specific B-cell responses in blood were significantly lower in pregnant ferrets. This model predicts that the poorer outcome for pregnant women during the A(H1N1)pdm09 pandemic was due to an elevated level of viral replication and to a cytokine imbalance that led to a less effective immune response.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/-
dc.relation.ispartofJournal of Infectious Diseases-
dc.subjectPregnancy-
dc.subjectPandemic influenza A virus-
dc.subjectImmune response-
dc.titleDysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus-
dc.typeArticle-
dc.identifier.emailZhu, H: zhuhch@hku.hk-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.authorityZhu, H=rp01535-
dc.identifier.authorityGuan, Y=rp00397-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/infdis/jix328-
dc.identifier.scopuseid_2-s2.0-85041172530-
dc.identifier.hkuros280543-
dc.identifier.volume217-
dc.identifier.issue3-
dc.identifier.spage438-
dc.identifier.epage442-
dc.identifier.isiWOS:000423169200014-
dc.publisher.placeUnited States-
dc.identifier.issnl0022-1899-

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