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Article: The aetiology of upper aerodigestive tract cancers among young adults in Europe: The ARCAGE study

TitleThe aetiology of upper aerodigestive tract cancers among young adults in Europe: The ARCAGE study
Authors
KeywordsEpidemiology
Larynx
Oral
Alcohol
Cancer
Tobacco
Diet
Pharynx
Issue Date2010
Citation
Cancer Causes and Control, 2010, v. 21, n. 12, p. 2213-2221 How to Cite?
AbstractBackground: The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption. Objective: To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years. Methods: A case-control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched. Results: There were 356 cases younger than 50 years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk. Conclusions: Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike. © 2010 Springer Science+Business Media B.V.
Persistent Identifierhttp://hdl.handle.net/10722/249046
ISSN
2023 Impact Factor: 2.2
2023 SCImago Journal Rankings: 0.934
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMacFarlane, Tatiana V.-
dc.contributor.authorMacFarlane, Gary J.-
dc.contributor.authorOliver, Richard J.-
dc.contributor.authorBenhamou, Simone-
dc.contributor.authorBouchardy, Christine-
dc.contributor.authorAhrens, Wolfgang-
dc.contributor.authorPohlabeln, Hermann-
dc.contributor.authorLagiou, Pagona-
dc.contributor.authorLagiou, Areti-
dc.contributor.authorCastellsague, Xavier-
dc.contributor.authorAgudo, Antonio-
dc.contributor.authorMerletti, Franco-
dc.contributor.authorRichiardi, Lorenzo-
dc.contributor.authorKjaerheim, Kristina-
dc.contributor.authorSlamova, Alena-
dc.contributor.authorSchejbalova, Miriam-
dc.contributor.authorCanova, Cristina-
dc.contributor.authorSimonato, Lorenzo-
dc.contributor.authorTalamini, Renato-
dc.contributor.authorBarzan, Luigi-
dc.contributor.authorConway, David I.-
dc.contributor.authorMcKinney, Patricia A.-
dc.contributor.authorZnaor, Ariana-
dc.contributor.authorLowry, Raymond J.-
dc.contributor.authorThomson, Peter-
dc.contributor.authorHealy, Claire M.-
dc.contributor.authorMcCartan, Bernard E.-
dc.contributor.authorMarron, Manuela-
dc.contributor.authorHashibe, Mia-
dc.contributor.authorBrennan, Paul-
dc.date.accessioned2017-10-27T05:58:57Z-
dc.date.available2017-10-27T05:58:57Z-
dc.date.issued2010-
dc.identifier.citationCancer Causes and Control, 2010, v. 21, n. 12, p. 2213-2221-
dc.identifier.issn0957-5243-
dc.identifier.urihttp://hdl.handle.net/10722/249046-
dc.description.abstractBackground: The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption. Objective: To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years. Methods: A case-control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched. Results: There were 356 cases younger than 50 years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk. Conclusions: Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike. © 2010 Springer Science+Business Media B.V.-
dc.languageeng-
dc.relation.ispartofCancer Causes and Control-
dc.subjectEpidemiology-
dc.subjectLarynx-
dc.subjectOral-
dc.subjectAlcohol-
dc.subjectCancer-
dc.subjectTobacco-
dc.subjectDiet-
dc.subjectPharynx-
dc.titleThe aetiology of upper aerodigestive tract cancers among young adults in Europe: The ARCAGE study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10552-010-9641-3-
dc.identifier.pmid20835759-
dc.identifier.scopuseid_2-s2.0-78751575496-
dc.identifier.volume21-
dc.identifier.issue12-
dc.identifier.spage2213-
dc.identifier.epage2221-
dc.identifier.eissn1573-7225-
dc.identifier.isiWOS:000288609600029-
dc.identifier.issnl0957-5243-

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