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- Publisher Website: 10.1093/annonc/mdr335
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- PMID: 21828376
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Article: Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study
Title | Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study |
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Authors | Macfarlane, T. V.Macfarlane, G. J.Thakker, N. S.Benhamou, S.Bouchardy, C.Ahrens, W.Pohlabeln, H.Lagiou, P.Lagiou, A.Castellsague, X.Agudo, A.Slamova, A.Plzak, J.Merletti, F.Richiardi, L.Talamini, R.Barzan, L.Kjaerheim, K.Canova, C.Simonato, L.Conway, D. I.Mckinney, P. A.Thomson, P.Sloan, P.Znaor, A.Healy, C. M.McCartan, B. E.Marron, M.Brennan, P. |
Keywords | Medical history Aspirin use Medication use Upper aerodigestive tract cancer Epidemiology Gastroesophageal reflux |
Issue Date | 2012 |
Citation | Annals of Oncology, 2012, v. 23, n. 4, p. 1053-1060 How to Cite? |
Abstract | Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/249061 |
ISSN | 2023 Impact Factor: 56.7 2023 SCImago Journal Rankings: 13.942 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Macfarlane, T. V. | - |
dc.contributor.author | Macfarlane, G. J. | - |
dc.contributor.author | Thakker, N. S. | - |
dc.contributor.author | Benhamou, S. | - |
dc.contributor.author | Bouchardy, C. | - |
dc.contributor.author | Ahrens, W. | - |
dc.contributor.author | Pohlabeln, H. | - |
dc.contributor.author | Lagiou, P. | - |
dc.contributor.author | Lagiou, A. | - |
dc.contributor.author | Castellsague, X. | - |
dc.contributor.author | Agudo, A. | - |
dc.contributor.author | Slamova, A. | - |
dc.contributor.author | Plzak, J. | - |
dc.contributor.author | Merletti, F. | - |
dc.contributor.author | Richiardi, L. | - |
dc.contributor.author | Talamini, R. | - |
dc.contributor.author | Barzan, L. | - |
dc.contributor.author | Kjaerheim, K. | - |
dc.contributor.author | Canova, C. | - |
dc.contributor.author | Simonato, L. | - |
dc.contributor.author | Conway, D. I. | - |
dc.contributor.author | Mckinney, P. A. | - |
dc.contributor.author | Thomson, P. | - |
dc.contributor.author | Sloan, P. | - |
dc.contributor.author | Znaor, A. | - |
dc.contributor.author | Healy, C. M. | - |
dc.contributor.author | McCartan, B. E. | - |
dc.contributor.author | Marron, M. | - |
dc.contributor.author | Brennan, P. | - |
dc.date.accessioned | 2017-10-27T05:59:00Z | - |
dc.date.available | 2017-10-27T05:59:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Annals of Oncology, 2012, v. 23, n. 4, p. 1053-1060 | - |
dc.identifier.issn | 0923-7534 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249061 | - |
dc.description.abstract | Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Annals of Oncology | - |
dc.subject | Medical history | - |
dc.subject | Aspirin use | - |
dc.subject | Medication use | - |
dc.subject | Upper aerodigestive tract cancer | - |
dc.subject | Epidemiology | - |
dc.subject | Gastroesophageal reflux | - |
dc.title | Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/annonc/mdr335 | - |
dc.identifier.pmid | 21828376 | - |
dc.identifier.scopus | eid_2-s2.0-84859483908 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1053 | - |
dc.identifier.epage | 1060 | - |
dc.identifier.eissn | 1569-8041 | - |
dc.identifier.isi | WOS:000302298000035 | - |
dc.identifier.issnl | 0923-7534 | - |