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Article: Rapamycin enhances the anti-angiogenesis and anti-proliferation ability of YM155 in oral squamous cell carcinoma

TitleRapamycin enhances the anti-angiogenesis and anti-proliferation ability of YM155 in oral squamous cell carcinoma
Authors
KeywordsRapamycin
YM155
angiogenesis
oral squamous cell carcinoma
proliferation
Issue Date2017
PublisherSpringer Netherlands. The Journal's web site is located at http://www.karger.com/TBI
Citation
Tumor Biology, 2017, v. 39, p. 1010428317706213 How to Cite?
AbstractYM155, a small molecule inhibitor of survivin, has been studied in many tumors. It has been shown that YM155 inhibited oral squamous cell carcinoma through promoting apoptosis and autophagy and inhibiting proliferation. It was found that YM155 also inhibited the oral squamous cell carcinoma-mediated angiogenesis through the inactivation of the mammalian target of rapamycin pathway. Rapamycin, a mammalian target of rapamycin inhibitor, played an important role in the proliferation and angiogenesis of oral squamous cell carcinoma cell lines. In our study, cell proliferation assay, transwell assay, tube formation assay, and western blot assay were used to investigate the synergistic effect of rapamycin on YM155 in oral squamous cell carcinoma. Either in vitro or in vivo, rapamycin and YM155 exerted a synergistic effect on the inhibition of survivin and vascular endothelial growth factor through mammalian target of rapamycin pathway. Overall, our results revealed that low-dose rapamycin strongly promoted the sensitivity of oral squamous cell carcinoma cell lines to YM155.
Persistent Identifierhttp://hdl.handle.net/10722/249575
ISSN
2016 Impact Factor: 3.650
2023 SCImago Journal Rankings: 0.576
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, KL-
dc.contributor.authorWang, YF-
dc.contributor.authorQin, JR-
dc.contributor.authorWang, F-
dc.contributor.authorYang, YT-
dc.contributor.authorZheng, L-
dc.contributor.authorLi, MH-
dc.contributor.authorKong, J-
dc.contributor.authorZhang, W-
dc.contributor.authorYang, HY-
dc.date.accessioned2017-11-21T03:04:08Z-
dc.date.available2017-11-21T03:04:08Z-
dc.date.issued2017-
dc.identifier.citationTumor Biology, 2017, v. 39, p. 1010428317706213-
dc.identifier.issn1010-4283-
dc.identifier.urihttp://hdl.handle.net/10722/249575-
dc.description.abstractYM155, a small molecule inhibitor of survivin, has been studied in many tumors. It has been shown that YM155 inhibited oral squamous cell carcinoma through promoting apoptosis and autophagy and inhibiting proliferation. It was found that YM155 also inhibited the oral squamous cell carcinoma-mediated angiogenesis through the inactivation of the mammalian target of rapamycin pathway. Rapamycin, a mammalian target of rapamycin inhibitor, played an important role in the proliferation and angiogenesis of oral squamous cell carcinoma cell lines. In our study, cell proliferation assay, transwell assay, tube formation assay, and western blot assay were used to investigate the synergistic effect of rapamycin on YM155 in oral squamous cell carcinoma. Either in vitro or in vivo, rapamycin and YM155 exerted a synergistic effect on the inhibition of survivin and vascular endothelial growth factor through mammalian target of rapamycin pathway. Overall, our results revealed that low-dose rapamycin strongly promoted the sensitivity of oral squamous cell carcinoma cell lines to YM155.-
dc.languageeng-
dc.publisherSpringer Netherlands. The Journal's web site is located at http://www.karger.com/TBI-
dc.relation.ispartofTumor Biology-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/[insert DOI]-
dc.subjectRapamycin-
dc.subjectYM155-
dc.subjectangiogenesis-
dc.subjectoral squamous cell carcinoma-
dc.subjectproliferation-
dc.titleRapamycin enhances the anti-angiogenesis and anti-proliferation ability of YM155 in oral squamous cell carcinoma-
dc.typeArticle-
dc.identifier.emailZheng, L: lwzheng@hkucc.hku.hk-
dc.identifier.authorityZheng, L=rp01411-
dc.identifier.doi10.1177/1010428317706213-
dc.identifier.pmid28618939-
dc.identifier.scopuseid_2-s2.0-85025127239-
dc.identifier.hkuros282714-
dc.identifier.volume39-
dc.identifier.spage1010428317706213-
dc.identifier.epage1010428317706213-
dc.identifier.isiWOS:000403686600001-
dc.publisher.placeNetherlands-
dc.identifier.issnl1010-4283-

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