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Article: A computational hemodynamics analysis on the correlation between energy loss and clinical outcomes for flow diverters treatment of intracranial aneurysm

TitleA computational hemodynamics analysis on the correlation between energy loss and clinical outcomes for flow diverters treatment of intracranial aneurysm
Authors
KeywordsComputational fluid dynamics (CFD)
Energy loss
Flow-diverter
Intracranial aneurysms
Issue Date2019
PublisherBiomedical Engineering Society of ROC, co-published with Springer. The Journal's web site is located at http://jmbe.bme.ncku.edu.tw/index.php?action=archives
Citation
Journal of Medical and Biological Engineering, 2019, v. 39 n. 1, p. 27-42 How to Cite?
AbstractThe rupture of intracranial aneurysms might lead to permanent disability or even death. One possible endovascular treatment is the deployment of flow diverters (FDs), which reduces flow into the sac and promotes thrombosis. Computational fluid dynamics simulations were used to assess the flow patterns and dynamics. The concept of energy loss, as a measure of necessary work done to overcome flow resistance, was utilized to correlate with clinical outcome. If a surgical operation is successful, the flow would be diverted to a shorter path and energy loss should be reduced. Conversely, persistent flow in the sac, associated with treatment failure, would display an increased energy loss as blood is then squeezed through the stent pores. Four illustrative clinical cases, involving both bifurcation and sidewall aneurysms, were selected. To reduce the numerical complexity, earlier works in the literature had used a porous medium approximation for the FDs. Here, the FD was simulated explicitly as a virtual (or computer-generated) stent, which would likely provide a more accurate description. Furthermore, quantitative comparisons between the approaches of virtual stenting and a porous medium with typical parameters were conducted by examining the effective flow influx into the aneurysm.
Persistent Identifierhttp://hdl.handle.net/10722/251438
ISSN
2020 Impact Factor: 1.553
2015 SCImago Journal Rankings: 0.387
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChiu, TL-
dc.contributor.authorTang, AYS-
dc.contributor.authorTsang, COA-
dc.contributor.authorLeung, GKK-
dc.contributor.authorChow, KW-
dc.date.accessioned2018-03-01T03:39:18Z-
dc.date.available2018-03-01T03:39:18Z-
dc.date.issued2019-
dc.identifier.citationJournal of Medical and Biological Engineering, 2019, v. 39 n. 1, p. 27-42-
dc.identifier.issn1609-0985-
dc.identifier.urihttp://hdl.handle.net/10722/251438-
dc.description.abstractThe rupture of intracranial aneurysms might lead to permanent disability or even death. One possible endovascular treatment is the deployment of flow diverters (FDs), which reduces flow into the sac and promotes thrombosis. Computational fluid dynamics simulations were used to assess the flow patterns and dynamics. The concept of energy loss, as a measure of necessary work done to overcome flow resistance, was utilized to correlate with clinical outcome. If a surgical operation is successful, the flow would be diverted to a shorter path and energy loss should be reduced. Conversely, persistent flow in the sac, associated with treatment failure, would display an increased energy loss as blood is then squeezed through the stent pores. Four illustrative clinical cases, involving both bifurcation and sidewall aneurysms, were selected. To reduce the numerical complexity, earlier works in the literature had used a porous medium approximation for the FDs. Here, the FD was simulated explicitly as a virtual (or computer-generated) stent, which would likely provide a more accurate description. Furthermore, quantitative comparisons between the approaches of virtual stenting and a porous medium with typical parameters were conducted by examining the effective flow influx into the aneurysm.-
dc.languageeng-
dc.publisherBiomedical Engineering Society of ROC, co-published with Springer. The Journal's web site is located at http://jmbe.bme.ncku.edu.tw/index.php?action=archives-
dc.relation.ispartofJournal of Medical and Biological Engineering-
dc.subjectComputational fluid dynamics (CFD)-
dc.subjectEnergy loss-
dc.subjectFlow-diverter-
dc.subjectIntracranial aneurysms-
dc.titleA computational hemodynamics analysis on the correlation between energy loss and clinical outcomes for flow diverters treatment of intracranial aneurysm-
dc.typeArticle-
dc.identifier.emailTang, AYS: aystang@hku.hk-
dc.identifier.emailTsang, COA: acotsang@hku.hk-
dc.identifier.emailLeung, GKK: gkkleung@hku.hk-
dc.identifier.emailChow, KW: kwchow@hku.hk-
dc.identifier.authorityTsang, COA=rp01519-
dc.identifier.authorityLeung, GKK=rp00522-
dc.identifier.authorityChow, KW=rp00112-
dc.description.naturepostprint-
dc.identifier.doi10.1007/s40846-018-0376-z-
dc.identifier.scopuseid_2-s2.0-85060705552-
dc.identifier.hkuros284246-
dc.identifier.volume39-
dc.identifier.issue1-
dc.identifier.spage27-
dc.identifier.epage42-
dc.identifier.isiWOS:000457198100003-
dc.publisher.placeTaiwan, Republic of China-
dc.identifier.issnl1609-0985-

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