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Article: Prognostic factors associated with clear cell sarcoma in 14 Chinese patients

TitlePrognostic factors associated with clear cell sarcoma in 14 Chinese patients
Authors
KeywordsClear cell
Tendons
Sarcoma
Issue Date2014
Citation
Journal of Orthopaedic Surgery, 2014, v. 22, n. 2, p. 236-239 How to Cite?
Abstract© 2014, Hong Kong University Press. All rights reserved. Purpose. To identify prognostic factors associated with clear cell sarcomas in 14 Chinese patients. Methods. Medical records of 7 men and 7 women (mean age, 36 years) with histologically confirmed clear cell sarcoma of tendons and aponeuroses were reviewed. Patient demographics, tumour characteristics, and treatment modalities were retrieved. Prognostic factors associated with favourable 5-year survival were determined. Results. The most affected sites were the thigh (n=5) and the foot (n=4); the mean time from symptom onset to diagnosis was 9.5 months. The tumour stage at diagnosis was IIA in 8 patients, IIB in 2, and III in 4. The mean tumour size was 4.5 cm in diameter. One patient was lost to follow-up. For the remaining 13 patients, the mean time to disease-related mortality was 2.5 years. Nine patients had distant metastases; the most common sites were lungs and pleura (n=7), followed by distant lymph nodes (n=4), bone (n=2), pericardium (n=2), and brain (n=1). All patients underwent surgical excision. Three women and one man (mea n age, 27 years) attained 5-year disease-free survival. All had stage IIA tumours at diagnosis. Their mean tumour size was 1.75 cm in diameter, which was significantly smaller than that of all patients (4.5 cm). Tumour size of ≤2.5 cm in diameter (p=0.004) and stage IIA tumour at diagnosis (p=0.04) were significant prognostic factors for 5-year survival. Conclusion. Tumour size of ≤2.5 cm and early stage tumour are associated with 5-year disease-free survival. Early detection is crucial for the prognosis of clear cell sarcomas.
Persistent Identifierhttp://hdl.handle.net/10722/251676
ISSN
2023 Impact Factor: 1.3
2023 SCImago Journal Rankings: 0.557
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, H. L.-
dc.contributor.authorHo, W. Y.-
dc.contributor.authorLam, Y. L.-
dc.contributor.authorNg, T. P.-
dc.contributor.authorLi, K. H.-
dc.contributor.authorShek, T.-
dc.contributor.authorMak, K. L.-
dc.contributor.authorFong, S. T.-
dc.contributor.authorSo, Y. C.-
dc.contributor.authorNgan, R. K.C.-
dc.contributor.authorLau, P. P.L.-
dc.contributor.authorChan, A. C.L.-
dc.date.accessioned2018-03-08T05:00:39Z-
dc.date.available2018-03-08T05:00:39Z-
dc.date.issued2014-
dc.identifier.citationJournal of Orthopaedic Surgery, 2014, v. 22, n. 2, p. 236-239-
dc.identifier.issn1022-5536-
dc.identifier.urihttp://hdl.handle.net/10722/251676-
dc.description.abstract© 2014, Hong Kong University Press. All rights reserved. Purpose. To identify prognostic factors associated with clear cell sarcomas in 14 Chinese patients. Methods. Medical records of 7 men and 7 women (mean age, 36 years) with histologically confirmed clear cell sarcoma of tendons and aponeuroses were reviewed. Patient demographics, tumour characteristics, and treatment modalities were retrieved. Prognostic factors associated with favourable 5-year survival were determined. Results. The most affected sites were the thigh (n=5) and the foot (n=4); the mean time from symptom onset to diagnosis was 9.5 months. The tumour stage at diagnosis was IIA in 8 patients, IIB in 2, and III in 4. The mean tumour size was 4.5 cm in diameter. One patient was lost to follow-up. For the remaining 13 patients, the mean time to disease-related mortality was 2.5 years. Nine patients had distant metastases; the most common sites were lungs and pleura (n=7), followed by distant lymph nodes (n=4), bone (n=2), pericardium (n=2), and brain (n=1). All patients underwent surgical excision. Three women and one man (mea n age, 27 years) attained 5-year disease-free survival. All had stage IIA tumours at diagnosis. Their mean tumour size was 1.75 cm in diameter, which was significantly smaller than that of all patients (4.5 cm). Tumour size of ≤2.5 cm in diameter (p=0.004) and stage IIA tumour at diagnosis (p=0.04) were significant prognostic factors for 5-year survival. Conclusion. Tumour size of ≤2.5 cm and early stage tumour are associated with 5-year disease-free survival. Early detection is crucial for the prognosis of clear cell sarcomas.-
dc.languageeng-
dc.relation.ispartofJournal of Orthopaedic Surgery-
dc.subjectClear cell-
dc.subjectTendons-
dc.subjectSarcoma-
dc.titlePrognostic factors associated with clear cell sarcoma in 14 Chinese patients-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/230949901402200226-
dc.identifier.pmid25163964-
dc.identifier.scopuseid_2-s2.0-84929515316-
dc.identifier.volume22-
dc.identifier.issue2-
dc.identifier.spage236-
dc.identifier.epage239-
dc.identifier.eissn2309-4990-
dc.identifier.isiWOS:000346631000026-
dc.identifier.issnl1022-5536-

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