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Conference Paper: Elucidating the molecular and epigenetic basis of centromere instability and premature sister chromatid cohesion separation

TitleElucidating the molecular and epigenetic basis of centromere instability and premature sister chromatid cohesion separation
Authors
KeywordsCentromere
Sister chromatid cohesion
Epigenetics
Issue Date2018
PublisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS
Citation
The 76th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, 28-30 September 2017. In Cancer Science, 2018, v. 109 n. S1, p. 417 How to Cite?
AbstractAneuploidy and numerical chromosome instability are hallmarks in solid tumors, which could be cause by elevated mitotic chromosome missegregation. The centromere is the specialized chromosomal domain responsible for assembling the kinetochore, which attaches microtubules to orchestrate chromosome movements. In atypical lipomas and well-differentiated liposarcomas (ALP-WDLPS) cells, chromosome rearrangements result in chromosome fragments that lack the endogenous centromere. Yet, a neocentromere can form on non-centromeric region in supernumerary ring or marker chromosomes. In other cases, neocentromeres may be formed with the inactivation of endogenous centromeres without any loss of sequence. Moreover, overexpression of kinetochore proteins can result in ectopic kinetochore formation in cancers. In addition, sister chromatid cohesion has to be established in S phase, and maintained until anaphase. Components of the cohesin ring and cohesion establishment factors are mutated at high frequency in colorectal cancers. Here I will discuss the epigenetic regulation of centromere activity and sister chromatid cohesion, and their potentials as therapeutic cancer targets.
DescriptionInternational Session: Chromosomal instability as a cause and a therapeutic target for cancer - no. IS5-1
Persistent Identifierhttp://hdl.handle.net/10722/252438
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.625

 

DC FieldValueLanguage
dc.contributor.authorLing, YH-
dc.contributor.authorYuen, KWY-
dc.date.accessioned2018-04-23T06:41:25Z-
dc.date.available2018-04-23T06:41:25Z-
dc.date.issued2018-
dc.identifier.citationThe 76th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, 28-30 September 2017. In Cancer Science, 2018, v. 109 n. S1, p. 417-
dc.identifier.issn1347-9032-
dc.identifier.urihttp://hdl.handle.net/10722/252438-
dc.descriptionInternational Session: Chromosomal instability as a cause and a therapeutic target for cancer - no. IS5-1-
dc.description.abstractAneuploidy and numerical chromosome instability are hallmarks in solid tumors, which could be cause by elevated mitotic chromosome missegregation. The centromere is the specialized chromosomal domain responsible for assembling the kinetochore, which attaches microtubules to orchestrate chromosome movements. In atypical lipomas and well-differentiated liposarcomas (ALP-WDLPS) cells, chromosome rearrangements result in chromosome fragments that lack the endogenous centromere. Yet, a neocentromere can form on non-centromeric region in supernumerary ring or marker chromosomes. In other cases, neocentromeres may be formed with the inactivation of endogenous centromeres without any loss of sequence. Moreover, overexpression of kinetochore proteins can result in ectopic kinetochore formation in cancers. In addition, sister chromatid cohesion has to be established in S phase, and maintained until anaphase. Components of the cohesin ring and cohesion establishment factors are mutated at high frequency in colorectal cancers. Here I will discuss the epigenetic regulation of centromere activity and sister chromatid cohesion, and their potentials as therapeutic cancer targets.-
dc.languageeng-
dc.publisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS-
dc.relation.ispartofCancer Science-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectCentromere-
dc.subjectSister chromatid cohesion-
dc.subjectEpigenetics-
dc.titleElucidating the molecular and epigenetic basis of centromere instability and premature sister chromatid cohesion separation-
dc.typeConference_Paper-
dc.identifier.emailYuen, KWY: kwyyuen@hku.hk-
dc.identifier.authorityYuen, KWY=rp01512-
dc.identifier.hkuros282493-
dc.identifier.volume109-
dc.identifier.issueS1-
dc.identifier.spage417-
dc.identifier.epage417-
dc.publisher.placeJapan-
dc.identifier.issnl1347-9032-

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