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Conference Paper: Tobacco exposure in adolescence and the risk of nasopharyngeal carcinoma: preliminary results from a multi-center case-control study in Hong Kong, China
Title | Tobacco exposure in adolescence and the risk of nasopharyngeal carcinoma: preliminary results from a multi-center case-control study in Hong Kong, China |
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Authors | |
Issue Date | 2018 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://isptid.globalink.org/journal/index.html |
Citation | The 17th World Conference on Tobacco or Health (WCTOH 2018), Cape Town, South Africa, 7-9 March 2018. In Tobacco Induced Diseases, 2018, v. 16 n. suppl. 1, p. 312, abstract no. A818 How to Cite? |
Abstract | Background:
Incidence of many cancers increases with age, but the incidence of nasopharyngeal carcinoma (NPC) in high-risk areas (e.g. Hong Kong) peaks at age 40-55 years. The early onset suggests an important role of early childhood exposures in NPC development. In our ongoing NPC case-control study, we examined the relationship between tobacco exposure especially in adolescence and NPC.
Methods:
We analysed 777 histologically confirmed NPC cases (mean age=52.8, SD=12.0), and 1,690 frequency matched non-NPC controls (mean age=50.4, SD=13.4) recruited during July 2014 to July 2017 from 5 of the largest hospitals (n=1,460) and 3 Red Cross Blood Transfusion Centres (n=230) in Hong Kong. Information on smoking and other factors was collected via a computer-assisted self-administered questionnaire. Re-interviewing of the 140 subjects showed good agreement of smoking history (Kappa or ICC: 0.65-0.99). Unconditional logistic regression was used to estimate odds ratios (ORs) of NPC for tobacco exposure, adjusting for 5-year age groups, sex, housing type at age 10, and alcohol drinking status.
Results:
Compared with never smokers, the OR (95%CIs) was 1.62 (1.32-1.98) for ever-smokers. The ORs were 2.27 (1.38-3.75) for starting smoking at 6-12 years and 1.65 (1.30-2.10) for 13-18 years (p for trend=0.001). For those who started at 6-18 years, the OR was 1.23 (0.79-1.93) for smoking 1-5 cigarettes/day, 1.71 (1.21-2.41) for 6-10 cigarettes/day and 1.78 (1.26-2.53) for 11+ cigarettes/day (p for trend< 0.001).
Conclusions:
Our preliminary results have shown that tobacco exposure in adolescence were associated with higher risk of NPC in a high-risk area. Further analysis will be conducted after case (target=800) and control (target=1900) recruitment is completed. |
Description | 4.2. Burden and Disparities in tobacco-related diseases: Non-communicable diseases (NCDs) and communicable diseases (TB and HIV/AIDS) - FO-393-4 |
Persistent Identifier | http://hdl.handle.net/10722/253521 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.780 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LIN, J | - |
dc.contributor.author | MAI, Z | - |
dc.contributor.author | Lam, TH | - |
dc.date.accessioned | 2018-05-21T02:59:02Z | - |
dc.date.available | 2018-05-21T02:59:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | The 17th World Conference on Tobacco or Health (WCTOH 2018), Cape Town, South Africa, 7-9 March 2018. In Tobacco Induced Diseases, 2018, v. 16 n. suppl. 1, p. 312, abstract no. A818 | - |
dc.identifier.issn | 1617-9625 | - |
dc.identifier.uri | http://hdl.handle.net/10722/253521 | - |
dc.description | 4.2. Burden and Disparities in tobacco-related diseases: Non-communicable diseases (NCDs) and communicable diseases (TB and HIV/AIDS) - FO-393-4 | - |
dc.description.abstract | Background: Incidence of many cancers increases with age, but the incidence of nasopharyngeal carcinoma (NPC) in high-risk areas (e.g. Hong Kong) peaks at age 40-55 years. The early onset suggests an important role of early childhood exposures in NPC development. In our ongoing NPC case-control study, we examined the relationship between tobacco exposure especially in adolescence and NPC. Methods: We analysed 777 histologically confirmed NPC cases (mean age=52.8, SD=12.0), and 1,690 frequency matched non-NPC controls (mean age=50.4, SD=13.4) recruited during July 2014 to July 2017 from 5 of the largest hospitals (n=1,460) and 3 Red Cross Blood Transfusion Centres (n=230) in Hong Kong. Information on smoking and other factors was collected via a computer-assisted self-administered questionnaire. Re-interviewing of the 140 subjects showed good agreement of smoking history (Kappa or ICC: 0.65-0.99). Unconditional logistic regression was used to estimate odds ratios (ORs) of NPC for tobacco exposure, adjusting for 5-year age groups, sex, housing type at age 10, and alcohol drinking status. Results: Compared with never smokers, the OR (95%CIs) was 1.62 (1.32-1.98) for ever-smokers. The ORs were 2.27 (1.38-3.75) for starting smoking at 6-12 years and 1.65 (1.30-2.10) for 13-18 years (p for trend=0.001). For those who started at 6-18 years, the OR was 1.23 (0.79-1.93) for smoking 1-5 cigarettes/day, 1.71 (1.21-2.41) for 6-10 cigarettes/day and 1.78 (1.26-2.53) for 11+ cigarettes/day (p for trend< 0.001). Conclusions: Our preliminary results have shown that tobacco exposure in adolescence were associated with higher risk of NPC in a high-risk area. Further analysis will be conducted after case (target=800) and control (target=1900) recruitment is completed. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://isptid.globalink.org/journal/index.html | - |
dc.relation.ispartof | Tobacco Induced Diseases | - |
dc.relation.ispartof | World Conference on Tobacco or Health (WCTOH) | - |
dc.rights | Tobacco Induced Diseases. Copyright © BioMed Central Ltd. | - |
dc.title | Tobacco exposure in adolescence and the risk of nasopharyngeal carcinoma: preliminary results from a multi-center case-control study in Hong Kong, China | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lam, TH: hrmrlth@hkucc.hku.hk | - |
dc.identifier.authority | Lam, TH=rp00326 | - |
dc.identifier.doi | 10.18332/tid/84207 | - |
dc.identifier.hkuros | 285168 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | suppl. 1 | - |
dc.identifier.spage | 312, abstract no. A818 | - |
dc.identifier.epage | 312, abstract no. A818 | - |
dc.identifier.isi | WOS:000431841800819 | - |
dc.publisher.place | United Kingdom | - |
dc.customcontrol.immutable | csl 180525 | - |
dc.identifier.issnl | 1617-9625 | - |