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- Publisher Website: 10.1016/j.vetmic.2014.11.016
- Scopus: eid_2-s2.0-84922716569
- PMID: 25529828
- WOS: WOS:000348952100020
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Article: Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant
Title | Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant |
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Authors | |
Keywords | Recombination PRRSV Pathogenicity Virulence |
Issue Date | 2015 |
Citation | Veterinary Microbiology, 2015, v. 175, n. 2-4, p. 332-340 How to Cite? |
Abstract | © 2014 Elsevier B.V. Porcine reproductive and respiratory syndrome virus (PRRSV) was first reported in China since late 1995 and several variants were further reported in subsequence years, causing huge economic losses to the Chinese swine industry. To date, three major lineages (lineage 3, 5.1 and 8.7) of Type 2 PRRSV were reported in China based on our global genotyping. The present study provides the epidemiology of the PRRSV in South China based on the isolates collected during 2009-2012, indicating three lineages (lineage 3, 5.1 and 8.7) of Type 2 PRRSV were still circulating in this area. Our phylogenetic reconstruction indicated that lineage 3 re-emerged in 2010 formed a huge cluster with closely related to the 2004 isolates from Hong Kong. Furthermore, the inter-lineage genomic recombination between MLV vaccine strain (lineage 5) and a recently re-emerged lineage 3 virus (QYYZ) has also been found in a farm practicing MLV vaccination. Our in vivo experiment comparing the pathogenicity and clinical presentations among currently isolated viruses indicated that pigs infected with recombinant lineage 3 virus (GM2) showed persistent higher fever compared to pigs infected by its wild counterpart (QYYZ). This study enhanced our understanding on potential importance of the recombination of PRRSV along with their evolution. |
Persistent Identifier | http://hdl.handle.net/10722/254438 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.653 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lu, Wen Hui | - |
dc.contributor.author | Tun, Hein Min | - |
dc.contributor.author | Sun, Bao Li | - |
dc.contributor.author | Mo, Jian Yui | - |
dc.contributor.author | Zhou, Qing Feng | - |
dc.contributor.author | Deng, Yu Xiu | - |
dc.contributor.author | Xie, Qing Mei | - |
dc.contributor.author | Bi, Ying Zuo | - |
dc.contributor.author | Leung, Frederick Chi Ching | - |
dc.contributor.author | Ma, Jing Yun | - |
dc.date.accessioned | 2018-06-19T15:40:32Z | - |
dc.date.available | 2018-06-19T15:40:32Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Veterinary Microbiology, 2015, v. 175, n. 2-4, p. 332-340 | - |
dc.identifier.issn | 0378-1135 | - |
dc.identifier.uri | http://hdl.handle.net/10722/254438 | - |
dc.description.abstract | © 2014 Elsevier B.V. Porcine reproductive and respiratory syndrome virus (PRRSV) was first reported in China since late 1995 and several variants were further reported in subsequence years, causing huge economic losses to the Chinese swine industry. To date, three major lineages (lineage 3, 5.1 and 8.7) of Type 2 PRRSV were reported in China based on our global genotyping. The present study provides the epidemiology of the PRRSV in South China based on the isolates collected during 2009-2012, indicating three lineages (lineage 3, 5.1 and 8.7) of Type 2 PRRSV were still circulating in this area. Our phylogenetic reconstruction indicated that lineage 3 re-emerged in 2010 formed a huge cluster with closely related to the 2004 isolates from Hong Kong. Furthermore, the inter-lineage genomic recombination between MLV vaccine strain (lineage 5) and a recently re-emerged lineage 3 virus (QYYZ) has also been found in a farm practicing MLV vaccination. Our in vivo experiment comparing the pathogenicity and clinical presentations among currently isolated viruses indicated that pigs infected with recombinant lineage 3 virus (GM2) showed persistent higher fever compared to pigs infected by its wild counterpart (QYYZ). This study enhanced our understanding on potential importance of the recombination of PRRSV along with their evolution. | - |
dc.language | eng | - |
dc.relation.ispartof | Veterinary Microbiology | - |
dc.subject | Recombination | - |
dc.subject | PRRSV | - |
dc.subject | Pathogenicity | - |
dc.subject | Virulence | - |
dc.title | Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.vetmic.2014.11.016 | - |
dc.identifier.pmid | 25529828 | - |
dc.identifier.scopus | eid_2-s2.0-84922716569 | - |
dc.identifier.volume | 175 | - |
dc.identifier.issue | 2-4 | - |
dc.identifier.spage | 332 | - |
dc.identifier.epage | 340 | - |
dc.identifier.eissn | 1873-2542 | - |
dc.identifier.isi | WOS:000348952100020 | - |
dc.identifier.issnl | 0378-1135 | - |